| Name | Human mtGPD |
|---|---|
| Supplier | ABBIOTEC |
| Catalog | 600275 |
| Category | Protein |
| Prices | $250.00 |
| Sizes | 10 µg |
| Species Reactivities | Human |
| Nature | Recombinant |
| Source | E. coli |
| Purity | Purity > 95% as determined by reducing and non-reducing SDS-PAGE, Bradford assay, Western blot and ELISA. |
| Gene | GPD2 |
| Sequence | His-Tag sequence not included: ADCISEPVNREPPSREAQLLTLQNTSEFDILVIGGGATGSGCALDAVTRGLKTALVERDD FSSGTSSRSTKLIHGGVRYLQKAIMKLDIEQYRMVKEALHERANLLEIAPHLSAPLPIML PVYKWWQLPYYWVGIKLYDLVAGSNCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQ HNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPQTGKVHVSGARCKDVLTGQEFDVR AKCVINATGPFTDSVRKMDDKDAAAICQPSAGVHIVMPGYYSPESMGLLDPATSDGRVIF FLPWQKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSCDVEVRRGDVLAAWSGIR PLVTDPKSADTQSISRNHVVDISESGLITIAGGKWTTYRSMAEDTINAAVKTHNLKAGPS RTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAATYGDKAFEVAKMASVTGKRWPIV GVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELN WDDYKKQEQLETARKFLY |
| Description | Mitochondrial glycerol-3-phosphate dehydrogenase (mtGPD) is a Ca2+-sensitive, FAD-binding protein located on the outer surface of the inner mitochondrial membrane. mtGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mtGPD. Isoform 1 comprises 727 aa residues, whereas isoform 2 lacks 126 aa residues of the N-terminus. Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin dependent diabetes mellitus. Recombinant mtGPD comprises a 558 amino acid fragment (43-600) corresponding to the GlpA domain fragment of the mature mtGPD protein and is expressed in E. coli with an amino-terminal hexahistidine tag. |
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