Recombinant Human Alpha Hemoglobin Stabilizing Protein

• Supplier: Genway Biotech
• Catalog: GWB-DB54EA
• Category: Protein
• Prices: $75.00, $165.00, $1,195.00
• Sizes: 10 μg, 50 μg, 1000 μg
• Species Reactivities: Human
• Nature: Recombinant
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• SwissProt/Accession: Q9NZD4
• Gene: AHSP
• Sequence: M A LLK A NKDLIS A GLK E FSVLLNQQVFNDPLVS E E DMVTVV E DWMNFYINYYRQQVTG E PQ E RDK A LQ E LRQ E LNTL A NPFL A KYRDFLKSH E LPSHPPPSS. Introduction: Alpha-hemoglobin stabilizing protein (AHSP) is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of ?-hemoglobin during normal erythroid cell development. AHSP specifically protects free ?-hemoglobin from precipitation in live cells and in solution. AHSP is expected to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Furthermore, AHSP promotes alpha globin chain stability in human erythropoiesis. In addition, the AHSP stabilizes the alpha-Hb chain, thus avoiding its precipitation and its ability to generate ROS, which is implicated in cell death. AHSP is expressed in blood and bone marrow. AHSP subunit is a monomer, it forms a heterodimer with free alpha-hemoglobin. On the other hand, AHSP does not bind beta-hemoglobin nor alpha2beta2 hemoglobin A. AHSP is downregulated in TSEs
• Description: Recombinant Human Alpha Hemoglobin Stabilizing Protein