Recombinant Ovine Leptin Antagonist Triple Mutant, PEG-tagged

• Supplier: Creative Biomart
• Catalog: LEP-264O
• Category: Protein
• Nature: Recombinant
• Source: Ovine
• Purity: Greater than 95.0% as determined by: (a) Gel filtration analysis. (b) Analysis by SDS-PAGE.
• Bioactivity: Pegylated triple antagonist is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Its in vitro activity is 6-8 fold lower than the non-pegylated antagonist but in vivo it has profound weight gain effect (as compared to the non-pegylated antagonist like in mouse leptin antagonists), resulting mainly from increased food intake.
• SwissProt/Accession: Q28603
• Gene: LEP
• Description: Pegylated Leptin Antagonist Triple Mutant Ovine Recombinant is a single non-glycosilated polypeptide chain containing 146 amino and additional Ala at N-terminus acids and having a molecular mass of ~ 35.6 kDa, Leptin was mutated, resulting in L39A/D40A/F41A mutant