Recombinant Human Nodal Protein

• Supplier: R&D Systems
• Catalog: 3218-ND
• Category: Protein
• Prices: $329.00
• Sizes: 25 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: E. coli -derived His238-Leu347, with an N-terminal Met
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Bioactivity: Measured by its ability to induce Smad2 phosphorylation in P19 mouse embryonal carcinoma cells. Yeo, C. et al . (2001) Mol. Cell. 7 :949. Approximately 100 ng/mL of Recombinant Human Nodal can effectively induce Smad2 phosphorylation.
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: Q96S42
• Gene: NODAL
• Sequence: Met

Product References

Nodal.Gdf1 heterodimers with bound prodomains enable serum-independent nodal - Nodal.Gdf1 heterodimers with bound prodomains enable serum-independent nodal

Fuerer C, Nostro MC, Constam DB. J Biol Chem. 2014 Jun 20;289(25):17854-71.

Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and - Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and

Esquivies L, Blackler A, Peran M, Rodriguez-Esteban C, Izpisua Belmonte JC, Booker E, Gray PC, Ahn C, Kwiatkowski W, Choe S. J Biol Chem. 2014 Jan 17;289(3):1788-97.

Nodal promotes invasive phenotypes via a mitogen-activated protein - Nodal promotes invasive phenotypes via a mitogen-activated protein

Quail DF, Zhang G, Findlay SD, Hess DA, Postovit LM. Oncogene. 2014 Jan 23;33(4):461-73.

Widespread potential for growth-factor-driven resistance to anticancer kinase - Widespread potential for growth-factor-driven resistance to anticancer kinase

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Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its - Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its

Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV. J Biol Chem. 2011 Aug 26;286(34):30034-46.

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone - A rapid and sensitive bioassay for the simultaneous measurement of multiple bone

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Activin a efficiently specifies definitive endoderm from human embryonic stem - Activin a efficiently specifies definitive endoderm from human embryonic stem

McLean AB, D'Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S. Stem Cells. 2007 Jan;25(1):29-38.

Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity - Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity

Watanabe K, Hamada S, Bianco C, Mancino M, Nagaoka T, Gonzales M, Bailly V, Strizzi L, Salomon DS. J Biol Chem. 2007 Dec 7;282(49):35772-86. Epub 2007 Oct 9.