Recombinant Human IL-26/AK155 Dimer Protein, CF

• Supplier: R&D Systems
• Catalog: 1870-IL/CF
• Category: Protein
• Prices: $339.00, $3,890.00
• Sizes: 10 µg, 500 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: E. coli -derived Lys22-Gln171, with an N-terminal Met
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Bioactivity: Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Hor, S. et al . (2004) J. Biol. Chem. 279 :33343. The ED 50 for this effect is 0.04-0.2 µg/mL.
• Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: Q9NPH9.1
• Gene: IL26
• Sequence: Met

Product References

Widespread potential for growth-factor-driven resistance to anticancer kinase - Widespread potential for growth-factor-driven resistance to anticancer kinase

Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J. Nature. 2012 Jul 26;487(7408):505-9.

IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory - IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory

Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre JP, Jeannin P. PLoS Biol. 2012;10(9):e1001395.

Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 - Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20

Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, Dickensheets H, Dumoutier L, Renauld JC, Zdanov A, Donnelly RP, Kotenko SV. J Immunol. 2004 Feb 15;172(4):2006-10.