Recombinant Human Netrin-4 Protein, CF

• Supplier: R&D Systems
• Catalog: 1254-N4/CF
• Category: Protein
• Prices: $329.00
• Sizes: 25 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived Val26-Lys628, with a C-terminal 10-His tag
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Bioactivity: Measured by its binding ability in a functional ELISA. Immobilized rrUNC5H2/Fc Chimera at 5 µg/mL (100 µL/well) can bind rhNetrin-4 with a linear range of 6-400 ng/mL.
• Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: Q9HB63.2
• Gene: NTN4
• Sequence: Val26

Product References

The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration. - The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration.

Villanueva AA, Falcon P, Espinoza N, R LS, Milla LA, Hernandez-SanMiguel E, Torres VA, Sanchez-Gomez P, Palma V. Oncotarget. 2017 Feb 7;8(6):9767-9782.

Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and - Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and

Akino T, Han X, Nakayama H, McNeish B, Zurakowski D, Mammoto A, Klagsbrun M, Smith E. Cancer Res. 2014 Jul 15;74(14):3716-26.

NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence. - NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence.

Li L, Hu Y, Ylivinkka I, Li H, Chen P, Keski-Oja J, Hyytiainen M. PLoS One. 2013 Nov 12;8(11):e80363.

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched - Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched

Sneddon JB, Borowiak M, Melton DA. Nature. 2012 Nov 29;491(7426):765-8.

Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. - Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.

Lejmi E, Leconte L, Pedron-Mazoyer S, Ropert S, Raoul W, Lavalette S, Bouras I, Feron JG, Maitre-Boube M, Assayag F, Feumi C, Alemany M, Jie TX, Merkulova T, Poupon MF, Ruchoux MM, Tobelem G, Sennlaub F, Plouet J. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12491-6. doi: