Recombinant Human Complement Component C1r Protein, CF

• Supplier: R&D Systems
• Catalog: 1807-SE
• Category: Protein
• Prices: $329.00
• Sizes: 10 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived Met1-Asp705, with a C-terminal 10-His tag
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Bioactivity: Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Gly-Arg-ThioBenzyl ester (Z-GR-SBzl), in the presence of 5,5’Dithio-bis (2-nitrobenzoic acid) (DTNB). Edwards, K.M. et al . (1999) J. Biol. Chem. 274 :30468. The specific activity is >1,500 pmol/min/µg, as measured under the described conditions. See Activity Assay Protocol on www.RnDSystems.com
• Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: NP_001724
• Gene: C1R
• Sequence: Ser18 (A chain) & Ile464 (B chain)

Product References

Complement C1 esterase inhibitor levels linked to infections and contaminated - Complement C1 esterase inhibitor levels linked to infections and contaminated

Zhou ZH, Chen T, Arora K, Hyams K, Kozlowski S. PLoS One. 2012;7(4):e34978.

Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-alpha production in - Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-alpha production in

Ruan BH, Li X, Winkler AR, Cunningham KM, Kuai J, Greco RM, Nocka KH, Fitz LJ, Wright JF, Pittman DD, Tan XY, Paulsen JE, Lin LL, Winkler DG. J Immunol. 2010 Oct 1;185(7):4213-22.

Unique phenotypes of C1s deficiency and abnormality caused by two compound - Unique phenotypes of C1s deficiency and abnormality caused by two compound

Abe K, Endo Y, Nakazawa N, Kanno K, Okubo M, Hoshino T, Fujita T. J Immunol. 2009 Feb 1;182(3):1681-8.