Recombinant Human Siglec-9 Fc Chimera Protein, CF

• Supplier: R&D Systems
• Catalog: 1139-SL
• Category: Protein
• Prices: $171.08, $329.00
• Sizes: 50 µg, 50 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived Human Siglec-9 (Gln18 - Gly348) Accession # Q9Y336 DIEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Bioactivity: Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED 50 for this effect is 1‑5 µg/mL.
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: Q9Y336
• Gene: SIGLEC9
• Sequence: No results obtained: Gln18 predicted

Product References

Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver - Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver

Ito T, Ishigami M, Matsushita Y, Hirata M, Matsubara K, Ishikawa T, Hibi H, Ueda M, Hirooka Y, Goto H, Yamamoto A. Sci Rep. 2017 Mar 8;7:44043.

Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model - Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model

Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N, Yamamoto A. Arthritis Res Ther. 2016 Jun 7;18(1):133.

Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte - Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte

Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A. J Neurosci. 2015 Feb 11;35(6):2452-64.

Broad and direct interaction between TLR and Siglec families of pattern - Broad and direct interaction between TLR and Siglec families of pattern

Chen GY, Brown NK, Wu W, Khedri Z, Yu H, Chen X, van de Vlekkert D, D'Azzo A, Zheng P, Liu Y. Elife. 2014 Sep 3;3:e04066.

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral - Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral

Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, Cicala C, Crocker P, Arthos J, Sun PD. PLoS One. 2011;6(9):e24559.