Recombinant Human ECE-1 Protein, CF

• Supplier: R&D Systems
• Catalog: 1784-ZN
• Category: Protein
• Prices: $329.00
• Sizes: 10 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived Gln90-Trp770, with an N-terminal signal peptide, 10-His tag and Val
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Bioactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH (Catalog # ES005 ). The specific activity is >2,500 pmol/min/µg, as measured under the described conditions. See Activity Assay Protocol on www.RnDSystems.com
• Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: P42892
• Gene: ECE1
• Sequence: His

Product References

Endothelin-converting enzyme-2 is increased in Alzheimer's disease and - Endothelin-converting enzyme-2 is increased in Alzheimer's disease and

Palmer JC, Baig S, Kehoe PG, Love S. Am J Pathol. 2009 Jul;175(1):262-70.

Endothelin-converting enzyme-1 degrades internalized somatostatin-14. - Endothelin-converting enzyme-1 degrades internalized somatostatin-14.

Roosterman D, Kempkes C, Cottrell GS, Padilla BE, Bunnett NW, Turck CW, Steinhoff M. Endocrinology. 2008 May;149(5):2200-7.

Immunocapture-based fluorometric assay for the measurement of neprilysin-specific - Immunocapture-based fluorometric assay for the measurement of neprilysin-specific

Miners JS, Verbeek MM, Rikkert MO, Kehoe PG, Love S. J Neurosci Methods. 2008 Jan 30;167(2):229-36. Epub 2007 Aug 25.

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin - Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin

Padilla BE, Cottrell GS, Roosterman D, Pikios S, Muller L, Steinhoff M, Bunnett NW. J Cell Biol. 2007 Dec 3;179(5):981-97. Epub 2007 Nov 26.