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NIPA Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects NIPA protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-NIPA antibody (B-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Nuclear Interaction Partner of ALK (NIPA) protein plays a pivotal role in regulating cyclin B1, which is essential for proper cell cycle progression. NIPA is primarily located in cytoplasm during interphase, where phosphorylation occurs during G2 and M phases, leading to cyclin B1 accumulation in the nucleus just before mitosis. This phosphorylation prevents premature mitotic entry by allowing cyclin B1 to accumulate until appropriate signaling occurs. When NIPA dephosphorylates, interaction with the SCF complex facilitates ubiquitination and subsequent degradation of cyclin B1, thus maintaining genomic stability. Dysregulation of NIPA can lead to abnormal cyclin B1 accumulation, resulting in premature mitotic entry and loss of checkpoint control, which are significant factors in cancer development. Additionally, phosphorylated NIPA may also play a role in apoptotic signaling pathways, highlighting NIPA′s importance in both cell cycle regulation and programmed cell death.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NIPA Antibody (B-10) | sc-365058 | 200 µg/ml | $316.00 | |||
NIPA Antibody (B-10): m-IgG1 BP-HRP Bundle | sc-531699 | 200 µg Ab; 20 µg BP | $354.00 | |||
NIPA Antibody (B-10) AC | sc-365058 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NIPA Antibody (B-10) HRP | sc-365058 HRP | 200 µg/ml | $316.00 | |||
NIPA Antibody (B-10) FITC | sc-365058 FITC | 200 µg/ml | $330.00 | |||
NIPA Antibody (B-10) PE | sc-365058 PE | 200 µg/ml | $343.00 | |||
NIPA Antibody (B-10) Alexa Fluor® 488 | sc-365058 AF488 | 200 µg/ml | $357.00 | |||
NIPA Antibody (B-10) Alexa Fluor® 546 | sc-365058 AF546 | 200 µg/ml | $357.00 | |||
NIPA Antibody (B-10) Alexa Fluor® 594 | sc-365058 AF594 | 200 µg/ml | $357.00 | |||
NIPA Antibody (B-10) Alexa Fluor® 647 | sc-365058 AF647 | 200 µg/ml | $357.00 | |||
NIPA Antibody (B-10) Alexa Fluor® 680 | sc-365058 AF680 | 200 µg/ml | $357.00 | |||
NIPA Antibody (B-10) Alexa Fluor® 790 | sc-365058 AF790 | 200 µg/ml | $357.00 |