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p21 Waf1/Cip1 Antibody (F-8) is a mouse monoclonal IgG2a kappa light chain antibody specific for an epitope mapping between amino acids 124-164 at the C-terminus of p21 Waf1/Cip1 of human origin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p21 Waf1/Cip1, also known as cyclin-dependent kinase inhibitor 1A (CDKN1A) or CAP20 in mice, is a critical regulator of the cell cycle, acting as an inhibitor of cyclin-dependent kinases (Cdks). p21 Waf1/Cip1 binds Cdks to prevent phosphorylation of the retinoblastoma protein (Rb), thereby halting cell cycle progression and promoting cellular responses such as senescence or apoptosis in reaction to DNA damage. p21 Waf1/Cip1 is primarily localized in the nucleus, where p21 Waf1/Cip1 interacts with cell cycle machinery, emphasizing its role in maintaining genomic stability and suppressing tumorigenesis. p21 Waf1/Cip1 expression is directly induced by wildtype p53 in response to cellular stress, linking p21 Waf1/Cip1 to pathways involved in DNA repair and cell survival. anti-p21 Waf1/Cip1 antibody (F-8) is available in both non-conjugated forms and a variety of conjugated formats, including agarose, horseradish peroxidase (HRP), and Alexa Fluor® dyes, enabling diverse experimental applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Waf1/Cip1/CDKN1A p21 Antibody (F-8) | sc-271610 | 200 µg/ml | $316.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-529221 | 200 µg Ab; 10 µg BP | $354.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-521996 | 200 µg Ab, 40 µg BP | $354.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) AC | sc-271610 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) HRP | sc-271610 HRP | 200 µg/ml | $316.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) FITC | sc-271610 FITC | 200 µg/ml | $330.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) PE | sc-271610 PE | 200 µg/ml | $343.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) Alexa Fluor® 488 | sc-271610 AF488 | 200 µg/ml | $357.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) Alexa Fluor® 546 | sc-271610 AF546 | 200 µg/ml | $357.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) Alexa Fluor® 594 | sc-271610 AF594 | 200 µg/ml | $357.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) Alexa Fluor® 647 | sc-271610 AF647 | 200 µg/ml | $357.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) Alexa Fluor® 680 | sc-271610 AF680 | 200 µg/ml | $357.00 | |||
Waf1/Cip1/CDKN1A p21 Antibody (F-8) Alexa Fluor® 790 | sc-271610 AF790 | 200 µg/ml | $357.00 | |||
Waf1/Cip1/CDKN1A p21 (F-8) Neutralizing Peptide | sc-271610 P | 100 µg/0.5 ml | $68.00 |