Bcl-6 Antibody (0.N.26): sc-70414
- Bcl-6 Antibody (0.N.26) is a mouse monoclonal IgG1, cited in 4 publications, provided at 250 µl supernatant
- raised against amino acids 3-484 of Bcl-6 of human origin
- recommended for detection of Bcl-6 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Bcl-6 (D-8): sc-7388 for Bcl-6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bcl-6 Antibody (0.N.26). This work is in progress.
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Bcl-6 Antibody (0.N.26) is a mouse monoclonal IgG1 antibody engineered to detect BCL6 protein across mouse, rat, and human species using western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) techniques. BCL6 monoclonal antibody (0.N.26) targets an epitope encompassing amino acids 3-484 at the N-terminus of human BCL6 protein, ensuring precise and reliable binding. BCL6 is a critical transcriptional repressor characterized by its unique structure, which includes a BTB/POZ domain responsible for protein-protein interactions and multiple zinc finger motifs that facilitate specific DNA binding. The structural integrity of BCL6 is essential for regulating gene expression, particularly in the development of germinal centers and the differentiation of T helper cells into Th1 and Th2 subsets, which are vital for the adaptive immune response. Additionally, the structured domains of BCL6 enable negative regulation of NFκB expression, thereby inhibiting NFκB-mediated cellular functions crucial for maintaining cellular homeostasis and preventing excessive inflammatory responses. BCL6 functionality is further modulated through HDAC- and SIR2-dependent acetylation, which alters structural conformation to downregulate activity by preventing the recruitment of histone deacetylase complexes. This intricate regulation underscores the importance of BCL6 structural domains in controlling various cellular processes. Dysregulation of BCL6 is frequently observed in non-Hodgkin′s B cell lymphomas, highlighting significance in oncogenesis and making BCL6 a valuable target for therapeutic intervention. The human BCL6 gene encodes a protein composed of 706 amino acids, reflecting complexity and essential functions in cellular biology. BCL6 (0.N.26) antibody is available in a non-conjugated form, providing researchers with a reliable tool to explore the multifaceted roles of BCL6 in immune regulation and disease, thereby facilitating advancements in both basic research and clinical applications.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-6 Antibody (0.N.26) | sc-70414 | 250 µl supernatant | $316.00 |