c-Fos Antibody (E-8): sc-166940
- c-Fos Antibody (E-8) is a mouse monoclonal IgG1 κ c-Fos antibody, cited in 170 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 128-152 within an internal region of c-Fos of human origin
- c-Fos Antibody (E-8) is recommended for detection of c-Fos, Fos B, Fra-1 and Fra-2 of mouse, rat, human, zebrafish and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-c-Fos Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-166940 X, 200 µg/0.1 ml)
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of c-Fos (E-8): sc-166940.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for c-Fos Antibody (E-8) for WB and IHC(P) applications. These reagents are now offered in bundles with c-Fos Antibody (E-8) (see ordering information below).
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c-Fos Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody raised against amino acids 128-152 of human c-Fos, a nuclear transcription factor essential for gene regulation. Anti-c-Fos antibody (E-8) recognizes an epitope within this region and demonstrates remarkably broad species cross-reactivity, detecting c-Fos, FosB, Fra-1, and Fra-2 in mouse, rat, human, zebrafish, equine, canine, bovine, porcine, and avian samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry on paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. While c-Fos primarily operates in the nucleus as a component of the AP-1 complex to regulate genes controlling cell proliferation, differentiation, and survival, c-Fos′s distribution patterns show interesting complexity. For instance, in pancreatic cancer cells, c-Fos appears in both nuclear and cytoplasmic locations, suggesting broader regulatory roles than previously understood. This dynamic localization becomes particularly significant when c-Fos regulation goes awry - overexpression or dysregulation of c-Fos can contribute to cancer development, while c-Fos also plays crucial roles in mediating apoptosis and cellular stress responses. Through these diverse cellular functions and broad species applications, c-Fos (E-8) antibody provides researchers with a valuable tool for investigating transcriptional regulation, stress responses, and cancer biology across multiple model systems.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
c-Fos Antibody (E-8) | sc-166940 | 200 µg/ml | $316.00 | |||
c-Fos Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-527195 | 200 µg Ab; 10 µg BP | $354.00 | |||
c-Fos Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-532568 | 200 µg Ab; 20 µg BP | $354.00 | |||
c-Fos Antibody (E-8) X | sc-166940 X | 200 µg/0.1 ml | $316.00 | |||
c-Fos Antibody (E-8) AC | sc-166940 AC | 500 µg/ml, 25% agarose | $416.00 | |||
c-Fos Antibody (E-8) HRP | sc-166940 HRP | 200 µg/ml | $316.00 | |||
c-Fos Antibody (E-8) FITC | sc-166940 FITC | 200 µg/ml | $330.00 | |||
c-Fos Antibody (E-8) PE | sc-166940 PE | 200 µg/ml | $343.00 | |||
c-Fos Antibody (E-8) Alexa Fluor® 488 | sc-166940 AF488 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (E-8) Alexa Fluor® 546 | sc-166940 AF546 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (E-8) Alexa Fluor® 594 | sc-166940 AF594 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (E-8) Alexa Fluor® 647 | sc-166940 AF647 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (E-8) Alexa Fluor® 680 | sc-166940 AF680 | 200 µg/ml | $357.00 | |||
c-Fos Antibody (E-8) Alexa Fluor® 790 | sc-166940 AF790 | 200 µg/ml | $357.00 | |||
c-Fos (E-8) Neutralizing Peptide | sc-166940 P | 100 µg/0.5 ml | $68.00 |