MEF-2D Antibody (H-11): sc-271153

MEF-2D Antibody (H-11) is a mouse monoclonal IgG3 kappa light chain antibody that detects MEF-2D protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-MEF-2D antibody (H-11) is available as the non-conjugated form. The myocyte enhancer factor-2 (MEF-2) family of transcription factors plays a crucial role in regulating the development and function of various cell types, including T cells, neuronal cells, and muscle cells. Among the four family members—MEF-2A, -2B, -2C, and -2D—MEF-2D is particularly important for muscle differentiation and gene expression. MEF-2D interacts with specific proteins, including myogenic basic helix-loop-helix proteins such as MyoD, myogenin, Myf-5, and MRF4, which are essential for muscle cell development. These interactions facilitate MEF-2D binding to the MEF-2 site in promoter regions of muscle-specific genes, thereby influencing transcriptional regulation. MEF-2D forms homo- and heterodimers with other MEF-2 family members, creating a complex regulatory network vital during embryogenesis and muscle development. Understanding MEF-2D function and interactions is essential for elucidating mechanisms underlying muscle differentiation and potential implications in muscle-related diseases.

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MEF-2D Antibody (H-11) References:

1. Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D.  |  Slepak, TI., et al. 2001. J Biol Chem. 276: 7575-85. PMID: 11096067
2. Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency.  |  Bryant, H. and Farrell, PJ. 2002. J Virol. 76: 10290-8. PMID: 12239305
3. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2.  |  Han, A., et al. 2003. Nature. 422: 730-4. PMID: 12700764
4. Lytic induction therapy for Epstein-Barr virus-positive B-cell lymphomas.  |  Feng, WH., et al. 2004. J Virol. 78: 1893-902. PMID: 14747554
5. Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.  |  Otani, K., et al. 2004. J Biol Chem. 279: 20915-20. PMID: 15014085
6. Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway.  |  Meissner, JD., et al. 2007. J Cell Physiol. 211: 138-48. PMID: 17111365
7. FGF22 promotes generation of ribbon synapses through downregulating MEF2D.  |  Li, S., et al. 2020. Aging (Albany NY). 12: 6456-6466. PMID: 32271716
8. MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis.  |  Shiozaki, Y., et al. 2022. Autophagy. 18: 1049-1061. PMID: 34517786
9. Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.  |  Chang, N., et al. 2023. Transl Cancer Res. 12: 287-300. PMID: 36915581
10. The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells.  |  Hidaka, K., et al. 1995. Biochem Biophys Res Commun. 213: 555-60. PMID: 7646512
11. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.  |  Hobson, GM., et al. 1995. Genomics. 29: 704-11. PMID: 8575763
12. Regulation of the MEF2 family of transcription factors by p38.  |  Zhao, M., et al. 1999. Mol Cell Biol. 19: 21-30. PMID: 9858528

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEF-2D Antibody (H-11) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-MEF-2D Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEF-2D Antibody (H-11) Specifications

Alternate Product Name: MEF2D

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 441-468

Epitope Target: MEF-2D

Epitope Species: human

Product Reactivity/Detection: MEF-2D

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for MEF-2D Antibody (H-11): P: Blocking Peptide, X: TransCruz Reagent