TIF1γ Antibody (XX-19): sc-101179

TIF1γ Antibody (XX-19) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIF1γ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-TIF1γ antibody (XX-19) is available as the non-conjugated form. TIF1γ protein plays a crucial role in mediating transcriptional regulation, particularly in response to transforming growth factor beta (TGFβ) signaling. TIF1γ protein interacts with Smad2/3 transcription factors, which are pivotal in TGFβ signaling pathway, influencing various cellular processes such as differentiation, proliferation, and apoptosis. TIF1γ protein′s ability to modulate these transcriptional effects is essential for maintaining cellular homeostasis and responding to environmental cues. TIF1γ protein is a member of the tripartite motif (TRIM) family, characterized by unique structural features, including three zinc-binding domains and a coiled-coil region, which facilitate interactions with other proteins and DNA. Understanding TIF1γ protein function and interactions is vital for elucidating its role in various biological processes and disease implications, making TIF1γ (XX-19) monoclonal antibody an invaluable tool for researchers studying transcriptional regulation and TGFβ signaling pathways.

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TIF1γ Antibody (XX-19) References:

1. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.  |  Venturini, L., et al. 1999. Oncogene. 18: 1209-17. PMID: 10022127
2. Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein.  |  Gebelein, B. and Urrutia, R. 2001. Mol Cell Biol. 21: 928-39. PMID: 11154279
3. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.  |  Schultz, DC., et al. 2001. Genes Dev. 15: 428-43. PMID: 11230151
4. A new twist in Smad signaling.  |  Heldin, CH. and Moustakas, A. 2006. Dev Cell. 10: 685-6. PMID: 16740469
5. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.  |  He, W., et al. 2006. Cell. 125: 929-41. PMID: 16751102
6. The Roles of TIF1γ in Cancer.  |  Yu, C., et al. 2019. Front Oncol. 9: 979. PMID: 31632911
7. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis.  |  Rossmann, MP., et al. 2021. Science. 372: 716-721. PMID: 33986176
8. TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.  |  Su, Z., et al. 2022. Cell Rep. 41: 111513. PMID: 36261009
9. E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma.  |  Li, Y., et al. 2023. Theranostics. 13: 4919-4935. PMID: 37771771
10. TIF1-gamma IgG2 isotype is not associated with malignancy in juvenile dermatomyositis patients.  |  Nguyen, HD., et al. 2024. Rheumatology (Oxford). 63: e281-e284. PMID: 38498839
11. KAP-1, a novel corepressor for the highly conserved KRAB repression domain.  |  Friedman, JR., et al. 1996. Genes Dev. 10: 2067-78. PMID: 8769649
12. Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.  |  Moosmann, P., et al. 1996. Nucleic Acids Res. 24: 4859-67. PMID: 9016654

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TIF1γ Antibody (XX-19) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-TIF1γ Antibody (XX-19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TIF1γ Antibody (XX-19) Specifications

Alternate Product Name: TIF1γ

Product Clone Name: XX-19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1006-1106

Epitope Target: TIF1γ

Epitope Species: human

Product Reactivity/Detection: TIF1γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for TIF1γ Antibody (XX-19): N/A