COQ2 Antibody (2B4): sc-517107

COQ2 Antibody (2B4) is a mouse monoclonal IgG1 kappa light chain antibody that detects the COQ2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-COQ2 antibody (2B4) is available as a non-conjugated format. COQ2, consisting of 374 amino acids, plays a crucial role in the biosynthesis of coenzyme Q (CoQ), an essential component of the mitochondrial respiratory chain that functions as an electron carrier in eukaryotic cells. COQ2 is vital for maintaining mitochondrial function and energy production, as COQ2 facilitates the transfer of electrons during oxidative phosphorylation, a process that generates ATP, the energy currency of the cell. Deficiencies in COQ2 can lead to impaired mitochondrial function, which is associated with various mitochondrial diseases and neurodegenerative disorders. Additionally, COQ2 has been shown to selectively inhibit the activity of mitochondrial DNA polymerase gamma, which is critical for mitochondrial DNA replication and repair, thereby highlighting COQ2′s importance in cellular energy metabolism and genetic stability. Anti-COQ2 antibody (2B4) is a valuable tool for researchers studying mitochondrial function, energy metabolism, and related pathologies.

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COQ2 Antibody (2B4) References:

1. Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.  |  Forsgren, M., et al. 2004. Biochem J. 382: 519-26. PMID: 15153069
2. Coenzyme Q2 induced p53-dependent apoptosis.  |  Esaka, Y., et al. 2005. Biochim Biophys Acta. 1724: 49-58. PMID: 15905035
3. A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency.  |  Quinzii, C., et al. 2006. Am J Hum Genet. 78: 345-9. PMID: 16400613
4. Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line.  |  Yonezawa, Y., et al. 2006. Cancer Sci. 97: 716-23. PMID: 16863505
5. Muscle coenzyme Q10 concentrations in patients with probable and definite diagnosis of respiratory chain disorders.  |  Montero, R., et al. 2005. Biofactors. 25: 109-15. PMID: 16873935
6. Human coenzyme Q10 deficiency.  |  Quinzii, CM., et al. 2007. Neurochem Res. 32: 723-7. PMID: 17094036
7. Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis.  |  López-Martín, JM., et al. 2007. Hum Mol Genet. 16: 1091-7. PMID: 17374725
8. Clinical, biochemical and molecular aspects of cerebellar ataxia and Coenzyme Q10 deficiency.  |  Montero, R., et al. 2007. Cerebellum. 6: 118-22. PMID: 17510911

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COQ2 Antibody (2B4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-COQ2 Antibody (2B4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COQ2 Antibody (2B4) Specifications

Alternate Product Name: COQ2

Product Clone Name: 2B4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 84-132

Epitope Target: COQ2

Epitope Species: human

Product Reactivity/Detection: COQ2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for COQ2 Antibody (2B4): N/A