LEPREL4 Antibody (FR-1): sc-130442
- LEPREL4 Antibody (FR-1) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant NOL55 of human origin
- recommended for detection of LEPREL4 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LEPREL4 Antibody (FR-1). This work is in progress.
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LEPREL4 Antibody (FR-1) is a mouse monoclonal IgG2a antibody that detects LEPREL4 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. LEPREL4, also known as leprecan-like protein 4, SC65, or NOL55, is a 437 amino acid protein belonging to the leprecan family, primarily located in the granular component of the nucleolus and associated with the surface of chromosomes during mitosis. LEPREL4 plays a crucial role in cellular processes, particularly in the regulation of gene expression and chromosomal organization, which are vital for proper cell division and function. Notably, LEPREL4 is post-translationally modified by phosphorylation at tyrosine 234, a modification that can influence activity and interactions with other proteins. The gene encoding LEPREL4 is situated on human chromosome 17, a region significant not only for high gene density, comprising over 1,200 genes, but also for association with key tumor suppressor genes such as p53 and BRCA1. These genes are essential for maintaining genomic stability and preventing tumorigenesis, highlighting LEPREL4′s importance in the broader context of cellular health and cancer research. Anti-LEPREL4 antibody (FR-1) enables researchers to gain insights into LEPREL4′s function and implications in various biological processes and diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LEPREL4 Antibody (FR-1) | sc-130442 | 100 µg/ml | $333.00 |