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RBQ-3 Antibody (D-7): sc-390954

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Datasheets
  • RBQ-3 Antibody (D-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 499-526 at the C-terminus of RBQ-3 of human origin
  • recommended for detection of RBQ-3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
  • m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for RBQ-3 Antibody (D-7) for WB applications. These reagents are now offered in bundles with RBQ-3 Antibody (D-7) (see ordering information below).

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    RBQ-3 Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects RBQ-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RBQ-3, also known as retinoblastoma binding protein 5 (RBBP5) or SWD1, is a 538 amino acid protein predominantly localized in the nucleus and features six WD repeats, which are critical for function. The presence of WD repeats allows RBQ-3 to participate in various cellular processes, including chromatin assembly and cell cycle regulation, by forming a tertiary propeller structure that facilitates protein-protein interactions. This structural characteristic is essential for RBQ-3′s role as a component of the Set1 complex, where RBQ-3 preferentially binds to underphosphorylated forms of the retinoblastoma (Rb) protein, thereby influencing cell proliferation. Additionally, RBQ-3 undergoes post-translational modifications, such as phosphorylation by ATM or ATR in response to DNA damage, which further underscores RBQ-3′s importance in maintaining genomic stability. With broad expression across tissues and involvement in critical regulatory mechanisms, anti-RBQ-3 antibody (D-7) serves as an invaluable tool for researchers studying cell cycle dynamics and related pathways.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    RBQ-3 Antibody (D-7)

    sc-390954
    200 µg/ml
    $316.00

    RBQ-3 Antibody (D-7): m-IgG Fc BP-HRP Bundle

    sc-540876
    200 µg Ab; 10 µg BP
    $354.00

    RBQ-3 Antibody (D-7): m-IgG1 BP-HRP Bundle

    sc-542434
    200 µg Ab; 20 µg BP
    $354.00

    RBQ-3 (D-7) Neutralizing Peptide

    sc-390954 P
    100 µg/0.5 ml
    $68.00

    What application is the blocking peptide sc-390954 P appropriate for?

    Asked by: jenniferc
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
    • y_2025, m_1, d_11, h_3CST
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    Rated 5 out of 5 by from Satisfactory Western blot data of RBQSatisfactory Western blot data of RBQ-3 expression in non-transfected and human RBQ-3 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-07-25
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    RBQ-3 Antibody (D-7) is rated 5.0 out of 5 by 1.
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