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RBQ-3 Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects RBQ-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RBQ-3, also known as retinoblastoma binding protein 5 (RBBP5) or SWD1, is a 538 amino acid protein predominantly localized in the nucleus and features six WD repeats, which are critical for function. The presence of WD repeats allows RBQ-3 to participate in various cellular processes, including chromatin assembly and cell cycle regulation, by forming a tertiary propeller structure that facilitates protein-protein interactions. This structural characteristic is essential for RBQ-3′s role as a component of the Set1 complex, where RBQ-3 preferentially binds to underphosphorylated forms of the retinoblastoma (Rb) protein, thereby influencing cell proliferation. Additionally, RBQ-3 undergoes post-translational modifications, such as phosphorylation by ATM or ATR in response to DNA damage, which further underscores RBQ-3′s importance in maintaining genomic stability. With broad expression across tissues and involvement in critical regulatory mechanisms, anti-RBQ-3 antibody (D-7) serves as an invaluable tool for researchers studying cell cycle dynamics and related pathways.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RBQ-3 Antibody (D-7) | sc-390954 | 200 µg/ml | $316.00 | |||
RBQ-3 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-540876 | 200 µg Ab; 10 µg BP | $354.00 | |||
RBQ-3 Antibody (D-7): m-IgG1 BP-HRP Bundle | sc-542434 | 200 µg Ab; 20 µg BP | $354.00 | |||
RBQ-3 (D-7) Neutralizing Peptide | sc-390954 P | 100 µg/0.5 ml | $68.00 |