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Nse2 Antibody

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Western Blot: Nse2 Antibody [NBP1-56293] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

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Nse2 Antibody Summary

Description
The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.
Immunogen
Synthetic peptides corresponding to NSMCE2(non-SMC element 2, MMS21 homolog (S. cerevisiae)) The peptide sequence was selected from the middle region of NSMCE2. Peptide sequence KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE. The peptide sequence for this immunogen was taken from within the described region.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NSMCE2
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1.0 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Affinity purified

Alternate Names for Nse2 Antibody

  • C8orf36
  • E3 SUMO-protein ligase NSE2
  • EC 6.3.2
  • EC 6.3.2.-
  • FLJ32440
  • hMMS21
  • methyl methanesulfonate sensitivity gene 21
  • MMS21 homolog
  • MMS21chromosome 8 open reading frame 36
  • non-SMC element 2 homolog (MMS21, S. cerevisiae)
  • Non-SMC element 2 homolog
  • non-SMC element 2, MMS21 homolog (S. cerevisiae)
  • Non-structural maintenance of chromosomes element 2 homolog
  • NSE2

Background

NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NSMCE2
Uniprot