PSMD2 Antibody (A-11): sc-271775
- PSMD2 Antibody (A-11) is a mouse monoclonal IgG2b κ PSMD2 antibody, cited in 9 publications, provided at 200 µg/ml
- raised against amino acids 491-790 mapping near the C-terminus of PSMD2 of human origin
- PSMD2 Antibody (A-11) is recommended for detection of PSMD2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-PSMD2 Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PSMD2 (A-11): sc-271775.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PSMD2 Antibody (A-11) for WB applications. These reagents are now offered in bundles with PSMD2 Antibody (A-11) (see ordering information below).
PSMD2 Antibody (A-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects PSMD2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSMD2 (A-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMD2, also known as proteasome (prosome, macropain) 26S subunit, non-ATPase 2, plays a crucial role in regulating the 26S proteasome, a vital proteolytic complex responsible for selective degradation of ubiquitinated proteins. This process maintains cellular homeostasis, regulates protein turnover, and controls various cellular processes, including cell cycle, apoptosis, and responses to oxidative stress. PSMD2 is predominantly expressed in skeletal muscle, brain, liver, placenta, kidney, pancreas, lung, and heart, where PSMD2 contributes to recognition and binding of substrate proteins, facilitating their degradation. Proper functioning of PSMD2 is critical, as dysregulation of the proteasome pathway can lead to various diseases, including cancer and neurodegenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMD2 Antibody (A-11) References:
- Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein. | Oberdorf, J., et al. 2006. J Cell Sci. 119: 303-13. PMID: 16390870
- Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. | Tan, Y., et al. 2006. J Burn Care Res. 27: 226-33. PMID: 16566573
- An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. | Stanhill, A., et al. 2006. Mol Cell. 23: 875-85. PMID: 16973439
- Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. | Deng, S., et al. 2007. Breast Cancer Res Treat. 104: 21-30. PMID: 17004105
- cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11. | Tsurumi, C., et al. 1996. Eur J Biochem. 239: 912-21. PMID: 8774743
- Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. | Hampton, RY., et al. 1996. Mol Biol Cell. 7: 2029-44. PMID: 8970163
- Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease. | Dunbar, JD., et al. 1997. J Immunol. 158: 4252-9. PMID: 9126987
- Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2. | Wilkinson, CR., et al. 1997. J Biol Chem. 272: 25768-77. PMID: 9325304
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMD2 Antibody (A-11) | sc-271775 | 200 µg/ml | $316.00 | |||
PSMD2 Antibody (A-11): m-IgGκ BP-HRP Bundle | sc-522059 | 200 µg Ab, 40 µg BP | $354.00 | |||
PSMD2 Antibody (A-11): m-IgG2b BP-HRP Bundle | sc-548998 | 200 µg Ab; 10 µg BP | $354.00 | |||
PSMD2 Antibody (A-11) AC | sc-271775 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PSMD2 Antibody (A-11) HRP | sc-271775 HRP | 200 µg/ml | $316.00 | |||
PSMD2 Antibody (A-11) FITC | sc-271775 FITC | 200 µg/ml | $330.00 | |||
PSMD2 Antibody (A-11) PE | sc-271775 PE | 200 µg/ml | $343.00 | |||
PSMD2 Antibody (A-11) Alexa Fluor® 488 | sc-271775 AF488 | 200 µg/ml | $357.00 | |||
PSMD2 Antibody (A-11) Alexa Fluor® 546 | sc-271775 AF546 | 200 µg/ml | $357.00 | |||
PSMD2 Antibody (A-11) Alexa Fluor® 594 | sc-271775 AF594 | 200 µg/ml | $357.00 | |||
PSMD2 Antibody (A-11) Alexa Fluor® 647 | sc-271775 AF647 | 200 µg/ml | $357.00 | |||
PSMD2 Antibody (A-11) Alexa Fluor® 680 | sc-271775 AF680 | 200 µg/ml | $357.00 | |||
PSMD2 Antibody (A-11) Alexa Fluor® 790 | sc-271775 AF790 | 200 µg/ml | $357.00 |