NCDN Antibody (F-12): sc-398588
- NCDN Antibody (F-12) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 17-44 near the N-terminus of NCDN of human origin
- recommended for detection of NCDN of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NCDN Antibody (F-12). This work is in progress.
QUICK LINKS
SEE ALSO...
NCDN Antibody (F-12) is a mouse monoclonal IgM antibody that detects neurochondrin (NCDN) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NCDN is a 729 amino acid leucine-rich cytoplasmic protein that plays a crucial role in nervous system signal transduction and is essential for spatial learning. NCDN functions as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMKII) phosphorylation, which is vital for various cellular processes, including synaptic plasticity and memory formation. NCDN interacts with melanin-concentrating hormone receptor 1 (MCH-1R), influencing MCH-1R activity and potentially impacting bone metabolism, neurite outgrowth, and chondrocyte differentiation. Three isoforms of NCDN result from alternative splicing, highlighting diverse functional roles, with these isoforms being predominantly expressed in the adult brain and spinal cord, while lower levels are found in the fetal brain, ovary, and testis. NCDN localizes to the somatic regions of neurons and is encoded by a gene located on human chromosome 1p34.3 and mouse chromosome 4 D2.2, underscoring NCDN significance in neurobiology and potential implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NCDN Antibody (F-12) References:
- Isolation of a new gene from the distal short arm of the human X chromosome that escapes X-inactivation. | Yen, PH., et al. 1992. Hum Mol Genet. 1: 47-52. PMID: 1284467
- Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). | Ménasché, G., et al. 2003. J Clin Invest. 112: 450-6. PMID: 12897212
- Genetics of pigmentary disorders. | Tomita, Y. and Suzuki, T. 2004. Am J Med Genet C Semin Med Genet. 131C: 75-81. PMID: 15452859
- Glutamine synthetase in legumes: recent advances in enzyme structure and functional genomics. | Betti, M., et al. 2012. Int J Mol Sci. 13: 7994-8024. PMID: 22942686
- The UVA-induced long non-coding RNA GS1-600G8.5 regulates the expression of IL-8. | Rünger, TM. and Yo, K. 2018. J Dermatol Sci. 90: 363-366. PMID: 29496359
- High profile backing for GS1 drive. | Hodgson, G. 2016. Health Estate. 70: 24-8. PMID: 29518303
- Generalization gradients for fear and disgust in human associative learning. | Wang, J., et al. 2021. Sci Rep. 11: 14210. PMID: 34244571
- Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs. | Xie, T., et al. 2024. Stem Cell Res Ther. 15: 22. PMID: 38273351
- Molecular features of luminal breast cancer defined through spatial and single-cell transcriptomics. | Yoshitake, R., et al. 2024. Clin Transl Med. 14: e1548. PMID: 38282415
- Identification of translin and trax as components of the GS1 strand-specific DNA binding complex enriched in brain. | Taira, E., et al. 1998. J Neurochem. 71: 471-7. PMID: 9681436
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NCDN Antibody (F-12) | sc-398588 | 200 µg/ml | $316.00 | |||
NCDN (F-12) Neutralizing Peptide | sc-398588 P | 100 µg/0.5 ml | $68.00 |