Chitotriosidase Antibody (A-3): sc-271282

Chitotriosidase Antibody (A-3) is a mouse monoclonal IgG2b antibody that detects Chitotriosidase in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Chitotriosidase is a crucial enzyme involved in the degradation of chitin, a polysaccharide found in the exoskeletons of arthropods and the cell walls of fungi, which plays a significant role in the immune response against chitin-containing pathogens. The presence of Chitotriosidase in activated human macrophages highlights its importance in innate immunity, as elevated plasma levels of this enzyme are often observed in patients with Gaucher disease, indicating its potential as a biomarker for disease progression. Additionally, Chitotriosidase expression is notably restricted to specific tissues, including the brain, skin, bone marrow, kidney, tongue, stomach, and testis, which underscores specialized functions in various physiological processes. The structural homology between Chitotriosidase and chitinases from lower organisms suggests evolutionary conservation of function, while interaction with other proteins, such as the acidic mammalian chitinase precursor (AMCase), further emphasizes Chitotriosidase′s role in Th2-mediated inflammation and potential implications in asthma and allergic diseases. Anti-Chitotriosidase antibody (A-3) is an essential tool for researchers investigating the multifaceted roles of this enzyme in health and disease.

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Chitotriosidase Antibody (A-3) References:

1. Human chitotriosidase-catalyzed hydrolysis of chitosan.  |  Eide, KB., et al. 2012. Biochemistry. 51: 487-95. PMID: 22192075
2. Human chitotriosidase CHIT1 cross reacts with mammalian-like substrates.  |  Larsen, T., et al. 2014. FEBS Lett. 588: 746-51. PMID: 24462685
3. Clinical utility of chitotriosidase enzyme activity in nephropathic cystinosis.  |  Elmonem, MA., et al. 2014. Orphanet J Rare Dis. 9: 155. PMID: 25407738
4. The relationship between chitotriosidase activity and tuberculosis.  |  Chen, M., et al. 2015. Epidemiol Infect. 143: 3196-202. PMID: 26418349
5. Chitotriosidase Activity in Plasma and COPD Exacerbations.  |  Harlander, M., et al. 2020. Lung. 198: 299-306. PMID: 31982942
6. Accuracy of chitotriosidase activity and CCL18 concentration in assessing type I Gaucher disease severity. A systematic review with meta-analysis of individual participant data.  |  Raskovalova, T., et al. 2021. Haematologica. 106: 437-445. PMID: 32001533
7. Chitotriosidase as a Novel Biomarker for Therapeutic Monitoring of Nephropathic Cystinosis.  |  Veys, KRP., et al. 2020. J Am Soc Nephrol. 31: 1092-1106. PMID: 32273301
8. Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy.  |  Freigang, M., et al. 2021. Orphanet J Rare Dis. 16: 330. PMID: 34321067
9. Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers.  |  Ünal Çetin, E., et al. 2021. Turk J Med Sci. 51: 3038-3046. PMID: 34579512
10. Chitotriosidase is a biomarker for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.  |  Hayer, SN., et al. 2022. Ann Clin Transl Neurol. 9: 1807-1812. PMID: 36271674

The preferred Chitotriosidase antibody is Chitotriosidase Antibody (A-11): sc-271460.