E-cadherin Antibody (1.B.54): sc-71009

E-cadherin Antibody (1.B.54) is a mouse monoclonal IgG1 antibody that detects E-cadherin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). E-cadherin plays a crucial role in maintaining epithelial tissue integrity by mediating cell-cell adhesion, which is essential for proper tissue architecture and function. E-cadherin is primarily located at the cell membrane, where E-cadherin forms adherens junctions with neighboring cells, thereby contributing to the formation of tight cellular layers that are vital for barrier functions in tissues such as the skin and the lining of the gastrointestinal tract. E-cadherin′s location is critical, as dysfunction or loss is often associated with increased cell motility and invasiveness, which are hallmarks of cancer progression. E-cadherin′s extracellular domain interacts with other cadherins and cytoplasmic proteins, including β-catenin, to facilitate signaling pathways that regulate cell proliferation and differentiation. Anti-E-cadherin antibody (1.B.54) is an invaluable tool for researchers studying cell adhesion mechanisms, epithelial integrity, and E-cadherin′s implications in various diseases, particularly in cancer research where expression levels can serve as a prognostic marker.

The preferred E-cadherin antibody is E-cadherin Antibody (G-10): sc-8426.