NCAM/CD56 Antibody (1213C3.D5): sc-59862

NCAM Antibody (1213C3.D5) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to target the Neural Cell Adhesion Molecule (NCAM), also known as CD56 or NCAM1. Raised against human small cell lung carcinoma, anti-NCAM antibody (1213C3.D5) effectively detects NCAM in mouse, rat, and human species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). NCAM is a pivotal cell surface glycoprotein involved in mediating cell-to-cell interactions, playing a crucial role in embryogenesis, neuronal differentiation, and synaptic plasticity. NCAM interacts with a variety of proteins, including fibroblast growth factor receptors (FGFRs), integrins, and intracellular signaling molecules such as Fyn and focal adhesion kinase (FAK), which are essential for processes like neurite outgrowth and cell migration. Multiple isoforms of NCAM arise from alternative splicing and polyadenylation, contributing to diverse functions in both normal physiology and the progression of neuroectodermally derived tumors. NCAM monoclonal antibody (1213C3.D5) is particularly recommended for detecting tumors such as neuroblastoma, medulloblastoma, astrocytoma, and retinoblastoma, where NCAM expression is a key marker. By facilitating the study of NCAM interactions and signaling pathways, NCAM (1213C3.D5) antibody serves as an invaluable tool for researchers investigating the molecular mechanisms underlying tumor biology and neural development.

The preferred NCAM/CD56 antibody is NCAM/CD56 Antibody (ERIC 1): sc-106.