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Render Timestamp: 2025-01-08T11:03:31.949Z
Commit: 199712eb9daea12d88cc0e67894a8a09f475f8cb
XML generation date: 2024-09-20 06:19:28.802
Product last modified at: 2025-01-01T09:00:44.663Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

Phospho-Tyrosine Mouse mAb (P-Tyr-102) (Fluorescein Conjugate) #9418

Inquiry Info. # 9418

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    Supporting Data

    REACTIVITY
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1

    Product Information

    Storage

    Supplied in PBS with 100 µg/ml BSA and 0.1% of sodium azide. Store at 4°C. Do not aliquot the antibody.

    Specificity / Sensitivity

    Phospho-Tyrosine Mouse mAb (P-Tyr-102) (Fluorescein Conjugate) is prepared by cross-linking fluorescein to the epsilon amine groups on lysines and amino-terminal amines. Fluorescein absorbs visible blue light at wavelength 490 nm and emits visible green light at 520 nm. This antibody is useful for immunocytochemical detection of tyrosine-phosphorylated proteins. It does not cross-react with proteins phosphorylated on threonine or serine. (U.S. Patent No's.: 6,441,140; 6,982,318; 7,259,022; 7,344,714; U.S.S.N. 11,484,485; and all foreign equivalents.)

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with phospho-Tyr-containing peptides . The antibody is purified by protein A chromatography.

    Background

    Tyrosine phosphorylation plays a key role in cellular signaling (1). Research studies have shown that in cancer, unregulated tyrosine kinase activity can drive malignancy and tumor formation by generating inappropriate proliferation and survival signals (2). Antibodies specific for phospho-tyrosine (3,4) have been invaluable reagents in these studies. The phospho-tyrosine monoclonal antibodies developed by Cell Signaling Technology are exceptionally sensitive tools for studying tyrosine phosphorylation and monitoring tyrosine kinase activity in high throughput drug discovery.
    For Research Use Only. Not For Use In Diagnostic Procedures.
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