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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > ACACB (mouse) Antibody (internal region)
ACACB (mouse) Antibody (internal region)
Peptide-affinity purified goat antibody
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Application 
| E |
|---|---|
| Primary Accession | O00763 |
| Other Accession | NP_598665.2, 100705 (mouse), 116719 (rat) |
| Predicted | Mouse, Rat, Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 276541 Da |
| Gene ID | 32 |
|---|---|
| Other Names | Acetyl-CoA carboxylase 2, 6.4.1.2, ACC-beta, Biotin carboxylase, 6.3.4.14, ACACB, ACC2, ACCB |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ACACB (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACACB (HGNC:85) |
|---|---|
| Synonyms | ACC2, ACCB |
| Function | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759) |
Research Areas
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$ 423.00
Cat# AF3636a
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