FIT
Chemical Name: N-[1-[2-(4-Isothiocyanatophenyl)ethyl]-4-piperidinyl]-N-phenylpropanamide
Purity: ≥99%
Biological Activity
Selective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Irreversible ligands with high selectivity toward δ or μ opiate receptors.
Rice et al.
Science, 1983;220:314 -
Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site.
Rothman et al.
Neuropeptides, 1985;6:227 -
μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fen. isothiocyanate.
Schoffelmeer et al.
Eur.J.Pharmacol., 1988;154:169
Product Datasheets
Citation for FIT
The citations listed below are publications that use Tocris products. Selected citations for FIT include:
1 Citation: Showing 1 - 1
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The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Authors: Gross Et al.
Am J Physiol Heart Circ Physiol 2006;291:H827
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