GMQ hydrochloride
Chemical Name: N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride
Purity: ≥98%
Biological Activity
GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline.
Alijevic and Kellenberger
J.Biol.Chem., 2012;287:36059 -
ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain.
Li et al.
Mol.Pain, 2010;6:88
Product Datasheets
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