GSK 1059615
Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
Purity: ≥98%
Biological Activity
GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Saadia et al.
Clin.Cancer Res., 2009;15:3029 -
Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
Knight et al.
ACS Med.Chem.Lett., 2010;1:39
Product Datasheets
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