RIP3 Antibody

Name RIP3 Antibody
Supplier ABBIOTEC
Catalog 253368
Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Applications ELISA ICC/IF IHC WB
Species Reactivities Mouse
Antigen KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse RIP3.
Purity/Format Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Description Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kappaB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
Gene Ripk3
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