Ripk3

Gene Symbol Ripk3
Entrez Gene 56532
Alt Symbol 2610528K09Rik, AW107945, Rip3
Species Mouse
Gene Type protein-coding
Description receptor-interacting serine-threonine kinase 3
Other Description RIP-3|RIP-like protein kinase 3|mRIP3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots Q8K2Y2 Q3U3Z9 G3X8V8 Q9QZL0
Accessions EDL36235 EDL36236 Q9QZL0 AA270784 AF178953 AAF03133 AK012177 AK154505 BAE32636 BC029210 AAH29210 BF658559 BY206463 BY209344 NM_001164107 NP_001157579 NM_001164108 NP_001157580 NM_019955 NP_064339
Function Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19590578, ECO:0000269|PubMed:24012422, ECO:0000269|PubMed:24019532, ECO:0000269|PubMed:24095729}.
Subcellular Location Cytoplasm, cytosol {ECO:0000305}. Cell membrane. Mitochondrion {ECO:0000305}.
Tissue Specificity Expressed in embryo and in adult spleen, liver, testis, heart, brain and lung.
Top Pathways Cytosolic DNA-sensing pathway, TNF signaling pathway

RIP3 Antibody (Rodent Specific) - 14401 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cells using RIP3 Antibody (Rodent Specific), or GAPDH (D16H11) XP® Rabbit mAb #5174 (lower).

RIP3 (C-16) - sc-47364 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RIP3 (C-20) - sc-47366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RIP3 antibody - ab62344 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RIP3 antibody (ab62344) at 1 µg/mlLane 1 : Whole cell lysate in the absence of RIP3 peptideLane 2 : Whole cell lysate in the presence of RIP3 peptide

RIPK3/RIP3 Antibody - NBP1-77299 from Novus Biologicals

Prices $129.00, $429.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RIPK3/RIP3 Antibody [NBP1-77299] - Analysis of RIP3 in HeLa cell lysate with RIP3 antibody at (A) 1 and (B) 2 ug/mL.

RIPK3/RIP3 Antibody - NBP1-45842 from Novus Biologicals

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RIPK3/RIP3 Antibody [NBP1-45842] - Analysis of RIP3 expression in NIH3T3 cell lysate.

Anti-RIP3 antibody produced in rabbit - R4277 from Sigma-Aldrich

Prices $342.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Western blot analysis of RIP3 in mouse 3T3 whole cell lysate in the absence (A) or presence (B) of blocking peptide with Anti-RIP3 (<B>Cat. No. R4277</B>) at 1 μg/mL.

Anti-RIP3 antibody produced in rabbit - PRS2283 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RIP3: <B>Cat. No. PRS2283</B> Immunohistochemistry of RIP3 in rat kidney tissue with RIP3 antibody at 5 μg/mL.

RIPK3-Antibody - AP50800 from Abgent, a WuXi AppTec company

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from mouse cerebellum tissue lysate,using RIPK3 Antibody(AP50800). AP50800 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

RIP3 antibody - 70R-11745 from Fitzgerald

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RIPK3 antibody - 20R-1514 from Fitzgerald

Prices $595.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RIPK3 Antibody - abx004160 from Abbexa

Host Rabbit
Clonality Polyclonal

RIPK3 Antibody - abx104444 from Abbexa

Host Rabbit
Clonality Polyclonal

RIPK3 / RIP3 antibody - AP30729PU-N from Acris Antibodies

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of RIP3 in rat kidney tissue with RIP3 antibody Cat.-No AP30729PU-N at 5 μg/ml.

RIPK3 / RIP3 antibody - PAB9018 from Acris Antibodies

Prices $500.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Ripk3 expression in NIH/3T3 cell lysate.

Rabbit Anti-RIP3 Antibody - 168-10231 from RayBiotech

Host Rabbit

RIP3 Antibody - 2283 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of RIP3 in HeLa cell lysate with RIP3 antibody at (A) 1 and (B) 2 μg/mL.

RIP3 Antibody - 253368 from ABBIOTEC

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of RIP3 in mouse 3T3 whole cell lysate in the absence (A) or presence (B) of blocking peptide with RIP3 Antibody (Cat. No. 253368) at 1 ug/ml.

RIP3 Antibody - 24109 from Signalway Antibody

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of RIP3 in mouse 3T3 whole cell lysate in the absence (A) or presence (B) of blocking peptide with RIP3 antibody at 1 ug/mL.

Anti-RIPK3 (aa 473-486) polyclonal antibody - CPBT-66153RR from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-RIPK3 (aa 473-486) polyclonal antibody - DPAB-L21016 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

RIP3 Polyclonal Antibody - PA5-19956 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of rat kidney cells using a RIP3 polyclonal antibody (Product # PA5-19956) at a 20 ug/mL dilution.

RIP3, Polyclonal Antibody - MBS223753 from MyBioSource

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RIP3, Polyclonal Antibody - MBS150424 from MyBioSource

Prices $140.00, $355.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal

RIP3 Antibody - 600-401-H16 from Rockland Immunochemicals Inc

Prices $319.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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