FAS Antibody

• Supplier: ABBIOTEC
• Catalog: 250645
• Prices: $277.00
• Sizes: 100 µg
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Applications: ELISA WB IHC
• Species Reactivities: Mouse
• Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of rat FAS.
• Purity/Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
• Description: The FAS antigen (CD95) is a 40-50 kDa cell surface glycoprotein that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. FAS is a receptor for TNFSF6/FASL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (asparte-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A), a childhood syndrome involving hemolytic anemia and thrombocytopenia.
• Gene: Fas