BRAF (1H12) Antibody

Name BRAF (1H12) Antibody
Supplier ABBIOTEC
Catalog 252864
Prices $356.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone 1H12
Applications ELISA ICC/IF IHC WB
Species Reactivities Human
Antigen Purified recombinant fragment of human BRAF expressed in E. coli.
Purity/Format Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Description BRAF (v-raf murine sarcoma viral oncogene homolog B1) is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428 and Thr439). B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region, the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highest levels in the cerebrum and testes and defects in braf are involved in a wide range of cancers. The BRAF gene mutation is frequently detected in papillary thyroid carcinoma, melanocytic nevi, primary cutaneous melanomas and colorectal cancers.
Gene Raf1
Supplier Page Shop

Product images