BRAF (1F12) Antibody

Name BRAF (1F12) Antibody
Supplier ABBIOTEC
Catalog 252685
Prices $436.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone 1H12F1, 1H12G10, 1F12F11C9
Applications ELISA IHC WB
Species Reactivities Human
Antigen Purified recombinant fragment of BRAF expressed in E. coli.
Purity/Format Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Description BRAF (v-raf murine sarcoma viral oncogene homolog B1) is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylation sites (Ser364, Ser428, and Thr439). B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highest levels in the cerebrum and testes. Defects in braf are involved in a wide range of cancers. The BRAF gene mutation is frequently detected in papillary thyroid carcinoma, melanocytic nevi, primary cutaneous melanomas and colorectal cancers.
Gene Raf1
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