PHLPP Antibody
| Name | PHLPP Antibody |
|---|---|
| Supplier | Novus Biologicals |
| Catalog | NB100-1810 |
| Prices | $369.00 |
| Sizes | 100 µg |
| Host | Rabbit |
| Clonality | Polyclonal |
| Applications | WB IP |
| Species Reactivities | Human |
| Antigen | The immunogen recognized by this antibody maps to a region between residues 1050 and 1100 of human PH Domain and Leucine Rich Repeat Protein Phosphatase using the numbering given in entry NP_919431.1 (GeneID 23239). |
| Purity/Format | Immunogen affinity purified |
| Description | Rabbit Polyclonal |
| Gene | PHLPP1 |
| Supplier Page | Shop |
Product images
![Immunoprecipitation: PHLPP Antibody [NB100-1810] - Detection of Human PHLPP on HeLa whole cell lysate using NB100-1810 and NB100-1811. Immunoprecipitated PHLPP blotted with NB100-1810.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_1/22306_PHLPP-Antibody-Immunoprecipitation-NB100-1810-img0002.jpg)
Immunoprecipitation: PHLPP Antibody [NB100-1810] - Detection of Human PHLPP on HeLa whole cell lysate using NB100-1810 and NB100-1811. Immunoprecipitated PHLPP blotted with NB100-1810.
Product References
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt - PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt
Brognard J, Sierecki E, Gao T, Newton AC. Mol Cell. 2007 Mar 23;25(6):917-31.
The phosphatase PHLPP controls the cellular levels of protein kinase C. - The phosphatase PHLPP controls the cellular levels of protein kinase C.
Gao T, Brognard J, Newton AC. J Biol Chem. 2008 Mar 7;283(10):6300-11. Epub 2007 Dec 27.
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of - Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of
Brognard J, Niederst M, Reyes G, Warfel N, Newton AC. J Biol Chem. 2009 May 29;284(22):15215-23.
IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous - IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous
Cleveland-Donovan K, Maile LA, Tsiaras WG, Tchkonia T, Kirkland JL, Boney CM. Endocrinology. 2010 Aug;151(8):3752-63.
Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt - Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt
Mistafa O, Ghalali A, Kadekar S, Hogberg J, Stenius U. J Biol Chem. 2010 Sep 3;285(36):27900-10.
mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity - mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity
Liu J, Stevens PD, Gao T. J Biol Chem. 2011 Feb 25;286(8):6510-20.
Mislocalization of the E3 ligase, beta-transducin repeat-containing protein 1 - Mislocalization of the E3 ligase, beta-transducin repeat-containing protein 1
Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. J Biol Chem. 2011 Jun 3;286(22):19777-88.