Anti-alpha Synuclein (phospho S129) antibody
| Name | Anti-alpha Synuclein (phospho S129) antibody |
|---|---|
| Supplier | Abcam |
| Catalog | ab59264 |
| Prices | $385.00 |
| Sizes | 100 µg |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | ICC/IF ICC/IF IHC-P ELISA IHC-F WB IHC-F |
| Species Reactivities | Mouse, Human |
| Antigen | Synthetic phosphopeptide derived from Human Synuclein around the phosphorylation site of serine 129 (M-P-SP-E-E) |
| Description | Rabbit Polyclonal |
| Gene | SNCA |
| Conjugate | Unconjugated |
| Supplier Page | Shop |
Product images
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab59264 at a dilution of 1/50-1/100. Left hand image - without immunising peptide; right hand image - with immunising peptide.
All lanes : Anti-alpha Synuclein (phospho S129) antibody (ab59264) at 1/1000 dilutionLane 1 : Whole tissue lysate prepared from young transgenic mouse overexpressing human alpha-synucleinLane 2 : Whole tissue lysate prepared from young transgenic mouse overexpressing human alpha-synucleinLane 3 : Whole tissue lysate prepared from young transgenic mouse overexpressing human alpha-synucleinLane 4 : Whole tissue lysate prepared from old transgenic mouse overexpressing human alpha-synucleinLane 5 : Whole tissue lysate prepared from old transgenic mouse overexpressing human alpha-synucleinLane 6 : Whole tissue lysate prepared from old transgenic mouse overexpressing human alpha-synucleinLane 7 : Whole tissue lysate prepared from KO mouseLysates/proteins at 50 µg per lane.SecondaryGoat anti-rabbit Ig (H+L) HRP at 1/1000 dilutiondeveloped using the ECL techniqueObserved band size : 18,19 kDa (why is the actual band size different from the predicted?)Additional bands at : 60 kDa,80 kDa. We are
Product References
Defined alpha-synuclein prion-like molecular assemblies spreading in cell - Defined alpha-synuclein prion-like molecular assemblies spreading in cell
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Novel AAV-based rat model of forebrain synucleinopathy shows extensive - Novel AAV-based rat model of forebrain synucleinopathy shows extensive
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Glucocerebrosidase depletion enhances cell-to-cell transmission of - Glucocerebrosidase depletion enhances cell-to-cell transmission of
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alpha-Synucleinopathy associated with G51D SNCA mutation: a link between - alpha-Synucleinopathy associated with G51D SNCA mutation: a link between
Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL. Acta Neuropathol. 2013 May;125(5):753-69.
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a - Deficits in dopaminergic transmission precede neuron loss and dysfunction in a
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TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E - TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E
Ling H, Kara E, Bandopadhyay R, Hardy J, Holton J, Xiromerisiou G, Lees A, Houlden H, Revesz T. Neurobiol Aging. 2013 Dec;34(12):2889.e5-9. doi:
alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein - alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein
Lastres-Becker I, Ulusoy A, Innamorato NG, Sahin G, Rabano A, Kirik D, Cuadrado A. Hum Mol Genet. 2012 Jul 15;21(14):3173-92.
Accumulation of alpha-synuclein triggered by presynaptic dysfunction. - Accumulation of alpha-synuclein triggered by presynaptic dysfunction.
Nakata Y, Yasuda T, Fukaya M, Yamamori S, Itakura M, Nihira T, Hayakawa H, Kawanami A, Kataoka M, Nagai M, Sakagami H, Takahashi M, Mizuno Y, Mochizuki H. J Neurosci. 2012 Nov 28;32(48):17186-96.
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein - Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein
Gan L, Vargas MR, Johnson DA, Johnson JA. J Neurosci. 2012 Dec 5;32(49):17775-87.
Contribution of Alanine-76 and Serine Phosphorylation in alpha-Synuclein Membrane - Contribution of Alanine-76 and Serine Phosphorylation in alpha-Synuclein Membrane
Fiske M, Valtierra S, Solvang K, Zorniak M, White M, Herrera S, Konnikova A, Brezinsky R, Debburman S. Parkinsons Dis. 2011;2011:392180.