SNCA

Gene Symbol SNCA
Entrez Gene 6622
Alt Symbol NACP, PARK1, PARK4, PD1
Species Human
Gene Type protein-coding
Description synuclein, alpha (non A4 component of amyloid precursor)
Other Description alpha-synuclein|non A-beta component of AD amyloid|synuclein alpha-140
Swissprots P37840 Q6IAU6 Q13701 A8K2A4 Q4JHI3
Accessions AAC02114 AAG30302 AAG30303 AAS57868 AAS83394 AAY40956 AAY88735 CAS01777 CAS01781 EAX06035 EAX06036 P37840 AI815523 AK290169 BAF82858 AY049786 AAL15443 BC013293 AAH13293 BC108275 AAI08276 CR457058 CAG33339 CR541653 CAG46454 CR736451 D31839 BAA06625 DA391115 DQ892564 ABM83490 EU176705 ABW03506 HQ830267 AEG20815 HQ830268 AEG20816 HQ830269 AEG20817 JN709859 AFA25669 JN709860 AFA25670 JN709861 AFA25671 JN709862 AFA25672 JN709863 AFA25673 JN709864 AFA25674 JN709865 AFA25675 JN709866 AFA25676 JN709867 AFA25677 JN709868 AFA25678 JN709869 AFA25679 L08850 AAA16117 L36674 AAA98493 L36675 AAA98487 XM_011532203 XP_011530505 XM_011532204 XP_011530506 XM_011532205 XP_011530507 XM_011532206 XP_011530508 XM_011532207 XP_011530509 XM_011532208 XP_011530510 NM_000345 NP_000336 NM_001146054 NP_001139526 NM_001146055 NP_001139527 NM_007308 NP_009292
Function May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Subcellular Location Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons.
Tissue Specificity Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Top Pathways Alzheimer's disease

α/β-Synuclein (Syn205) Mouse mAb - 2644 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone Syn205
Western blot analysis of extracts from mouse and rat brain, using α/β-Synuclein (Syn205) Mouse mAb.

α-Synuclein Antibody - 2642 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293, HeLa, rat brain and mouse brain cell extracts, using α-Synuclein Antibody.

α-Synuclein Antibody (IF Preferred) - 2628 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human cerebellum and mouse brain using α-Synuclein (IF Preferred) Antibody.

α-Synuclein (Syn204) Mouse mAb - 2647 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone Syn204
Western blot analysis of extracts from human cerebellum and HeLa cells, using α-Synuclein (Syn204) Mouse mAb.

α-synuclein (211) - sc-12767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-synuclein (211): sc-12767. Western blot analysis of α-synuclein expression in SH-SYSY whole cell lysate.

α-synuclein (2B2D1) - sc-53955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-synuclein (2B2D1): sc-53955. Western blot analysis of human recombinant α-synuclein.

α-synuclein (LB 509) - sc-58480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-synuclein (LB 509): sc-58480. Western blot analysis of α-synuclein expression in human brain (A) and human recombinant α-synuclein 25 ng (B), and 200 ng (C).

α-synuclein (SPM451) - sc-52979 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-synuclein (SPM451): sc-52979. Western blot analysis of α-synuclein expression in human brain (A) and human brain frontal lobe (B) tissue extracts.

α-synuclein (Syn 204) - sc-32280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-synuclein (Syn 204): sc-32280. Western blot analysis of α-synuclein expression in human brain (A) and human brain frontal lobe (B) tissue extracts.

α-synuclein (3G282) - sc-69978 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-synuclein (3G282): sc-69978. Western blot analysis of α-synuclein expression in non-transfected: sc-117752 (A) and human α-synuclein transfected: sc-111729 (B) 293T whole cell lysates.

α-synuclein (3H2897) - sc-69977 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
α-synuclein (3H2897): sc-69977. Western blot analysis of α-synuclein expression in non-transfected: sc-117752 (A) and human α-synuclein transfected: sc-111729 (B) 293T whole cell lysates.

α/β-synuclein (Syn 202) - sc-32281 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α/β-synuclein (Syn 202): sc-32281. Western blot analysis of α-synuclein and β-synuclein expression in SK-N-MC whole cell lysate (A) and mouse brain tissue extract (B).

α/β-synuclein (3B6) - sc-69699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
α/β-synuclein (3B6): sc-69699. Western blot analysis of α-synuclein expression in non-transfected: sc-117752 (A) and human α-synuclein transfected: sc-111729 (B) 293T whole cell lysates.

nitrated α-synuclein (Syn514) - sc-32279 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
nitrated α-synuclein (Syn514): sc-32279. Western blot analysis of human recombinant nitrated α-synuclein.

nitrated α-synuclein (4H316) - sc-71703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

nitrated α/β-synuclein (Syn12) - sc-32278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
nitrated α/β-synuclein (Syn12): sc-32278. Western blot analysis of untreated (A) and nitrated (B) human recombinant α-synuclein.

nitrated α/β-synuclein (4H317) - sc-71702 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-α-synuclein (Tyr 125) - sc-293091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-α-synuclein (Tyr 125): sc-293091. Western blot analysis of α-synuclein phosphorylation expression in untreated (A) and anisomycin treated (B) C2C12 whole cell lysates.

p-α-synuclein (Ser 129) - sc-135638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of phosphorylated α-synuclein expression in mouse brain tissues. Blots were probed with p-α-synuclein (Ser 129): sc-135638 preincubated with cognate phosphorylated peptide (A) and p-α-synuclein (Ser 129): sc-135638 (B).

p-α-synuclein (Tyr 133) - sc-293092 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-α-synuclein (Tyr 133): sc-293092. Western blot analysis of α-synuclein phosphorylation expression in untreated (A) and anisomycin treated (B) C2C12 whole cell lysates.

p-α-synuclein (Tyr 136) - sc-293093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of α-synuclein phosphorylation expression in mouse brain tissue extract (A,B). Blots were probed with p-α-synuclein (Tyr 136): sc-293093 preincubated with its cognate phosphorylated peptide (A,B).

γ-synuclein (1H10D2) - sc-65979 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
γ-synuclein (1H10D2): sc-65979. Western blot analysis of human recombinant synuclein, γ (BCSGI).

Anti-alpha Synuclein (phospho S129) antibody - ab59264 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab59264 at a dilution of 1/50-1/100. Left hand image - without immunising peptide; right hand image - with immunising peptide.

Anti-alpha Synuclein (phospho S129) antibody - ab42906 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab42906 staining alpha Synuclein (phospho S129) in human SH-SY5Y cells by Flow Cytometry. Cells were fixed with paraformaldehyde and permeabilized. The sample was incubated with the primary antibody (1/200) for 1 hour at 20°C. A Phycoerythrin-conjugated goat anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody.Gating Strategy: isotype population (shown in white).See Abreview

Anti-alpha Synuclein (phospho S129) antibody [EP1536Y] - ab51253 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1536Y
All lanes : Anti-alpha Synuclein (phospho S129) antibody [EP1536Y] (ab51253) at 1/5000 dilutionLane 1 : Fetal brain lysate, untreatedLane 2 : Fetal brain lysate, treated with APLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP labeled at 1/2000 dilution
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