Gene Symbol | AACS |
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Entrez Gene | 65985 |
Alt Symbol | ACSF1, SUR-5 |
Species | Human |
Gene Type | protein-coding |
Description | acetoacetyl-CoA synthetase |
Other Description | acetoacetate-CoA ligase|acyl-CoA synthetase family member 1|homolog of C. elegans supressor of ras 5 (sur-5)|protein sur-5 homolog |
Swissprots | Q8IWD2 Q9BSJ9 Q8NEW5 Q49AC3 Q49AB9 Q658Q8 Q86V21 Q9H829 Q9HA19 |
Accessions | CCQ43707 EAW98473 EAW98474 EAW98475 Q86V21 AB054121 BAD22560 AK022451 BAB14040 AK022740 BAB14216 AK024036 BAB14793 AK024760 BAB14991 AK123245 AK304176 BAG65058 AK308779 AL833047 CAH56309 AY091468 AAM44124 BC004997 AAH04997 BC036694 AAH36694 BC040490 AAH40490 BC040574 AAH40574 BC041000 AAH41000 BC051862 AAH51862 XM_005253609 XP_005253666 XM_005253610 XP_005253667 XM_005253611 XP_005253668 XM_011538692 XP_011536994 XR_242960 NM_023928 NP_076417 |
Function | Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. |
Tissue Specificity | Highly expressed in kidney, heart and brain, but low in liver. {ECO:0000269|PubMed:12623130}. |
Top Pathways | Valine, leucine and isoleucine degradation, Butanoate metabolism |
ACSF1 CRISPR/Cas9 KO Plasmid (h) - sc-410613 from Santa Cruz Biotechnology
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ACSF1 HDR Plasmid (h) - sc-410613-HDR from Santa Cruz Biotechnology
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ACSF1 Double Nickase Plasmid (h) - sc-410613-NIC from Santa Cruz Biotechnology
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ACSF1 Double Nickase Plasmid (h2) - sc-410613-NIC-2 from Santa Cruz Biotechnology
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ACSF1 CRISPR Activation Plasmid (h) - sc-410613-ACT from Santa Cruz Biotechnology
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ACSF1 CRISPR Activation Plasmid (h2) - sc-410613-ACT-2 from Santa Cruz Biotechnology
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ACSF1 Lentiviral Activation Particles (h) - sc-410613-LAC from Santa Cruz Biotechnology
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ACSF1 Lentiviral Activation Particles (h2) - sc-410613-LAC-2 from Santa Cruz Biotechnology
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ACSF1 siRNA (h) - sc-96244 from Santa Cruz Biotechnology
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ACSF1 shRNA Plasmid (h) - sc-96244-SH from Santa Cruz Biotechnology
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ACSF1 shRNA (h) Lentiviral Particles - sc-96244-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU084121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2600 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2600 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08259 from Sigma-Aldrich
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AACS siRNA (Human) - CRJ2212 from Cohesion Biosciences
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AACS - MBS8240589 from MyBioSource
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shRNA set against Human AACS (NM_023928.3) - SHH228518 from Creative biogene
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shRNA set against Human AACS(NM_023928.3) - SHG021779 from Creative biogene
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AACS shRNA Plasmid (Human) - CHJ2212 from Cohesion Biosciences
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AACS miRNA 3'UTR clone - MiUTR1H-00006 from Creative biogene
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