Gene Symbol | NOL8 |
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Entrez Gene | 55035 |
Alt Symbol | C9orf34, NOP132, bA62C3.3, bA62C3.4 |
Species | Human |
Gene Type | protein-coding |
Description | nucleolar protein 8 |
Other Description | nucleolar protein Nop132 |
Swissprots | Q5TCC8 Q9H586 Q5TCD3 Q9H795 Q9H9J6 Q76FK4 Q9NWM4 Q5TCC7 Q5TCD6 Q5TCD7 Q7L3E2 Q76D35 Q9NWA4 Q9H7W7 Q5TCD5 |
Accessions | EAW62814 EAW62815 EAW62816 Q76FK4 AB105104 BAD12268 AB109030 BAC99315 AK000743 BAA91356 AK001049 BAA91479 AK022755 BAB14229 AK024245 BAB14857 AK024786 BAB15003 AK225322 AK297355 BAG59803 AK307408 BC008491 BC013788 AAH13788 BC035041 BC064942 BC146810 AAI46811 BF906161 CR627363 CAH10464 DA470513 XM_006717166 XP_006717229 XM_006717167 XP_006717230 XM_006717168 XP_006717231 XM_006717169 XP_006717232 XM_006717170 XP_006717233 XM_006717172 XP_006717235 XM_006717173 XP_006717236 XM_011518824 XP_011517126 XM_011518825 XP_011517127 XM_011518826 XP_011517128 XM_011518827 XP_011517129 XM_011518828 XP_011517130 XR_929816 NM_001256394 NP_001243323 NM_017948 NP_060418 NR_046106 |
Function | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis. |
Tissue Specificity | Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. {ECO:0000269|PubMed:15132771}. |
Nop132 CRISPR/Cas9 KO Plasmid (h) - sc-412423 from Santa Cruz Biotechnology
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Nop132 HDR Plasmid (h) - sc-412423-HDR from Santa Cruz Biotechnology
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Nop132 Double Nickase Plasmid (h) - sc-412423-NIC from Santa Cruz Biotechnology
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Nop132 Double Nickase Plasmid (h2) - sc-412423-NIC-2 from Santa Cruz Biotechnology
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Nop132 CRISPR Activation Plasmid (h) - sc-412423-ACT from Santa Cruz Biotechnology
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Nop132 CRISPR Activation Plasmid (h2) - sc-412423-ACT-2 from Santa Cruz Biotechnology
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Nop132 Lentiviral Activation Particles (h) - sc-412423-LAC from Santa Cruz Biotechnology
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Nop132 Lentiviral Activation Particles (h2) - sc-412423-LAC-2 from Santa Cruz Biotechnology
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Nop132 siRNA (h) - sc-92977 from Santa Cruz Biotechnology
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Nop132 shRNA Plasmid (h) - sc-92977-SH from Santa Cruz Biotechnology
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Nop132 shRNA (h) Lentiviral Particles - sc-92977-V from Santa Cruz Biotechnology
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NOL8 RNAi - H00055035-R01 from Novus Biologicals
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MISSION® esiRNA - EHU073001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15403 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15403 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03959 from Sigma-Aldrich
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NOL8 siRNA (Human) - CRJ0423 from Cohesion Biosciences
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Human NOL8 siRNA - orb270924 from Biorbyt
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NOL8 shRNA Plasmid (Human) - CHJ0423 from Cohesion Biosciences
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NOL8 miRNA 3'UTR clone - MiUTR3H-11964 from Creative biogene
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