| Gene Symbol | PHC2 |
|---|---|
| Entrez Gene | 1912 |
| Alt Symbol | EDR2, HPH2, PH2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polyhomeotic homolog 2 (Drosophila) |
| Other Description | early development regulator 2 (homolog of polyhomeotic 2)|early development regulatory protein 2|polyhomeotic 2|polyhomeotic-like 2|polyhomeotic-like protein 2 |
| Swissprots | Q8TAG8 Q6ZQR1 Q2TAL3 Q6NUJ6 A1L4Q1 A8KA40 Q9Y4Y7 Q96BL4 Q8IXK0 D3DPR2 Q5T0C1 Q8N306 |
| Accessions | EAX07457 EAX07458 EAX07459 EAX07460 EAX07461 EAX07462 Q8IXK0 AJ242730 CAB44779 AJ419231 CAD11673 AK055807 AK056429 BAG51706 AK091856 AK128821 BAC87622 AK292905 BAF85594 AK294426 BAG57672 BC015450 AAH15450 BC018602 BC028396 AAH28396 BC029269 AAH29269 BC068573 AAH68573 BC092492 AAH92492 BC110863 AAI10864 BC130630 AAI30631 BC144121 AAI44122 BX537498 CA949539 CD109667 U89278 AAC51170 XM_005270570 XP_005270627 XM_005270571 XP_005270628 XM_005270572 XP_005270629 XM_011540874 XP_011539176 XM_011540875 XP_011539177 XM_011540876 XP_011539178 XM_011540877 XP_011539179 XM_011540878 XP_011539180 XR_946566 NM_004427 NP_004418 NM_198040 NP_932157 |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:21282530}. |
PHC2 CRISPR/Cas9 KO Plasmid (h) - sc-407705 from Santa Cruz Biotechnology
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PHC2 HDR Plasmid (h) - sc-407705-HDR from Santa Cruz Biotechnology
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PHC2 Double Nickase Plasmid (h) - sc-407705-NIC from Santa Cruz Biotechnology
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PHC2 Double Nickase Plasmid (h2) - sc-407705-NIC-2 from Santa Cruz Biotechnology
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PHC2 CRISPR Activation Plasmid (h) - sc-407705-ACT from Santa Cruz Biotechnology
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PHC2 CRISPR Activation Plasmid (h2) - sc-407705-ACT-2 from Santa Cruz Biotechnology
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PHC2 Lentiviral Activation Particles (h) - sc-407705-LAC from Santa Cruz Biotechnology
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PHC2 Lentiviral Activation Particles (h2) - sc-407705-LAC-2 from Santa Cruz Biotechnology
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PHC2 siRNA (h) - sc-88797 from Santa Cruz Biotechnology
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PHC2 shRNA Plasmid (h) - sc-88797-SH from Santa Cruz Biotechnology
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PHC2 shRNA (h) Lentiviral Particles - sc-88797-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU080361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16712 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16712 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09058 from Sigma-Aldrich
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PHC2 siRNA (Human) - CRH1331 from Cohesion Biosciences
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shRNA set against Human PHC2 (NM_198040.2) - SHH374560 from Creative biogene
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shRNA set against Human PHC2(NM_198040.2) - SHR110360 from Creative biogene
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shRNA set against Human PHC2(NM_004427.3) - SHR110460 from Creative biogene
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shRNA set against Human PHC2(NM_198040.2) - SHR110488 from Creative biogene
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PHC2 shRNA Plasmid (Human) - CHH1331 from Cohesion Biosciences
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PHC2 miRNA 3'UTR clone - MiUTR1H-07842 from Creative biogene
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PHC2 miRNA 3'UTR clone - MiUTR1H-07843 from Creative biogene
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