ADAM28
| Gene Symbol | ADAM28 |
|---|---|
| Entrez Gene | 10863 |
| Alt Symbol | ADAM 28, MDC-L, MDCL, eMDC II, eMDCII |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADAM metallopeptidase domain 28 |
| Other Description | disintegrin and metalloproteinase domain-containing protein 28|epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II|epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II|metalloproteinase-like, disintegrin-like, and cysteine-rich protein-L |
| Swissprots | B2RMV5 Q9UKQ2 Q9Y3S0 Q9Y339 |
| Accessions | EAW63608 EAW63609 Q9UKQ2 AF137334 AAD25099 AF137335 AAD25100 AI475787 AI624552 AJ242015 CAB42085 AK225921 AK293382 BAG56894 AK303437 BAG64485 BC136478 AAI36479 BC144140 BE833805 BM992381 DA933009 XM_005273380 XP_005273437 XM_005273382 XP_005273439 XM_006716273 XP_006716336 XM_006716274 XP_006716337 XM_006716275 XP_006716338 XM_011544366 XP_011542668 XM_011544367 XP_011542669 XM_011544368 XP_011542670 XM_011544369 XP_011542671 XM_011544370 XP_011542672 XM_011544371 XP_011542673 XR_247120 XR_949375 NM_001304351 NP_001291280 NM_014265 NP_055080 NM_021777 NP_068547 NR_130709 NR_130710 |
| Function | May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. |
| Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen. |
ADAM28 CRISPR/Cas9 KO Plasmid (h) - sc-404031 from Santa Cruz Biotechnology
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ADAM28 HDR Plasmid (h) - sc-404031-HDR from Santa Cruz Biotechnology
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ADAM28 Double Nickase Plasmid (h) - sc-404031-NIC from Santa Cruz Biotechnology
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ADAM28 Double Nickase Plasmid (h2) - sc-404031-NIC-2 from Santa Cruz Biotechnology
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ADAM28 CRISPR Activation Plasmid (h) - sc-404031-ACT from Santa Cruz Biotechnology
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ADAM28 CRISPR Activation Plasmid (h2) - sc-404031-ACT-2 from Santa Cruz Biotechnology
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ADAM28 Lentiviral Activation Particles (h) - sc-404031-LAC from Santa Cruz Biotechnology
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ADAM28 Lentiviral Activation Particles (h2) - sc-404031-LAC-2 from Santa Cruz Biotechnology
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ADAM28 siRNA (h) - sc-105041 from Santa Cruz Biotechnology
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ADAM28 shRNA Plasmid (h) - sc-105041-SH from Santa Cruz Biotechnology
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ADAM28 shRNA (h) Lentiviral Particles - sc-105041-V from Santa Cruz Biotechnology
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ADAM28 RNAi - H00010863-R02 from Novus Biologicals
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ADAM28 RNAi - H00010863-R01 from Novus Biologicals
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MISSION® esiRNA - EHU051671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2815 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2815 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07280 from Sigma-Aldrich
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ADAM28 siRNA (Human) - CRH7397 from Cohesion Biosciences
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ADAM28 - MBS829071 from MyBioSource
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shRNA set against Human ADAM28 (NM_014265.4) - SHH231562 from Creative biogene
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shRNA set against Human ADAM28(NM_014265.4) - SHG038627 from Creative biogene
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shRNA set against Human ADAM28(NM_021777.3) - SHG038681 from Creative biogene
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Human ADAM28 siRNA - orb267899 from Biorbyt
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ADAM28 shRNA Plasmid (Human) - CHH7397 from Cohesion Biosciences
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ADAM28 miRNA 3'UTR clone - MiUTR1H-00160 from Creative biogene
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