| Gene Symbol |
Sin3b
|
| Entrez Gene |
20467
|
| Alt Symbol |
2810430C10Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transcriptional regulator, SIN3B (yeast)
|
| Other Description |
SIN3 homolog B, transcription regulator|histone deacetylase complex subunit Sin3b|paired amphipathic helix protein Sin3b|transcriptional corepressor Sin3b|transcriptional regulator, SIN3 yeast homolog B
|
| Swissprots |
O54976 Q6A013 Q62141 Q8VDZ5 Q8VCB8
|
| Accessions |
EDL10813 EDL10814 EDL10815 EDL10816 EDL10817 Q62141 AF038848 AAC04821 AI834948 AK013202 AK087970 AK146847 BAE27478 AK153801 BAE32188 AK159076 BAE34795 AK165592 BAE38280 AK169433 BAE41174 AK173005 BAD32283 AK187217 AK219747 BC020049 AAH20049 BC021160 AAH21160 BC051536 AAH51536 BC096367 BC129859 BF318403 CA463922 CK031698 CX211072 L38622 AAA69774 XM_006530789 XP_006530852 NM_001113248 NP_001106719 NM_009188 NP_033214
|
| Function |
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. {ECO:0000269|PubMed:10620510, ECO:0000269|PubMed:7889570}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00810, ECO:0000269|PubMed:20170641, ECO:0000269|PubMed:7889570}.
|