Gene Symbol | RGS6 |
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Entrez Gene | 9628 |
Alt Symbol | GAP |
Species | Human |
Gene Type | protein-coding |
Description | regulator of G-protein signaling 6 |
Other Description | GTPase activating protein|H_DJ1108A12.1|S914|WUGSC:H_DJ0283M22.1|WUGSC:H_DJ1108A12.1|regulator of G-protein signalling 6 |
Swissprots | Q8TE21 Q7Z4K4 Q8TE19 Q8TE13 Q9UDT0 Q9UDS8 Q8TE18 Q8TE17 O75577 Q9Y245 Q8TE16 Q7Z4K5 Q8TE14 Q8TE15 Q8TE20 P49758 C9JE95 Q7Z4K6 Q8TE22 O75576 Q9Y647 Q7Z4K3 F8W7W5 |
Accessions | AAC83180 AAD05031 AAM03004 AAM03005 AAM03006 AAM03007 AAM03008 AAM03009 AAM03010 AAM03011 AAM03012 AAM03013 EAW81062 EAW81063 EAW81064 EAW81065 EAW81066 EAW81067 EAW81068 EAW81069 EAW81070 EAW81071 P49758 AB209462 BAD92699 AF073920 AAC26049 AF073921 AAC26050 AF107619 AAD34717 AF107620 AAD34718 AF156932 AAD40183 AK125540 AK294486 BAH11786 AK294895 BAH11917 AK302319 BAH13671 AK310463 AK313481 BAG36265 AY309097 AAP74386 AY309098 AAP74387 AY309099 AAP74388 AY309100 AAP74389 BC104877 AAI04878 BC113572 AAI13573 BC143699 BX096120 BX537512 DC343081 HQ258438 ADR83192 L40394 AAC42001 XM_005268235 XP_005268292 XM_005268236 XP_005268293 XM_011537388 XP_011535690 XM_011537389 XP_011535691 XM_011537390 XP_011535692 XM_011537391 XP_011535693 XM_011537392 XP_011535694 XM_011537393 XP_011535695 XM_011537394 XP_011535696 XM_011537395 XP_011535697 XM_011537396 XP_011535698 XM_011537397 XP_011535699 XM_011537398 XP_011535700 XM_011537399 XP_011535701 XM_011537400 XP_011535702 XM_011537401 XP_011535703 XM_011537402 XP_011535704 XM_011537403 XP_011535705 XM_011537404 XP_011535706 XM_011537405 XP_011535707 XM_011537406 XP_011535708 XM_011537407 XP_011535709 XM_011537408 XP_011535710 XR_943565 NM_001204416 NP_001191345 NM_001204417 NP_001191346 NM_001204418 NP_001191347 NM_001204419 NP_001191348 NM_001204420 NP_001191349 NM_001204421 NP_001191350 NM_001204422 NP_001191351 NM_001204423 NP_001191352 NM_001204424 NP_001191353 NM_004296 NP_004287 |
Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. {ECO:0000269|PubMed:10521509}. |
Subcellular Location | Cytoplasm. Membrane; Peripheral membrane protein. |
RGS6 CRISPR/Cas9 KO Plasmid (h) - sc-404102 from Santa Cruz Biotechnology
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RGS6 HDR Plasmid (h) - sc-404102-HDR from Santa Cruz Biotechnology
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RGS6 Double Nickase Plasmid (h) - sc-404102-NIC from Santa Cruz Biotechnology
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RGS6 Double Nickase Plasmid (h2) - sc-404102-NIC-2 from Santa Cruz Biotechnology
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RGS6 CRISPR Activation Plasmid (h) - sc-404102-ACT from Santa Cruz Biotechnology
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RGS6 CRISPR Activation Plasmid (h2) - sc-404102-ACT-2 from Santa Cruz Biotechnology
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RGS6 Lentiviral Activation Particles (h) - sc-404102-LAC from Santa Cruz Biotechnology
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RGS6 Lentiviral Activation Particles (h2) - sc-404102-LAC-2 from Santa Cruz Biotechnology
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RGS6 siRNA (h) - sc-40665 from Santa Cruz Biotechnology
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RGS6 shRNA Plasmid (h) - sc-40665-SH from Santa Cruz Biotechnology
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RGS6 shRNA (h) Lentiviral Particles - sc-40665-V from Santa Cruz Biotechnology
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RGS6 RNAi - H00009628-R01 from Novus Biologicals
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MISSION® esiRNA - EHU087101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18231 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09671 from Sigma-Aldrich
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RGS6 siRNA (Human) - CRH6408 from Cohesion Biosciences
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RGS6 - MBS8215744 from MyBioSource
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RGS6 CRISPR/Cas9 KO Plasmid (h2) - sc-404102-KO-2 from Santa Cruz Biotechnology
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RGS6 HDR Plasmid (h2) - sc-404102-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human RGS6 (NM_004296.5) - SHH395001 from Creative biogene
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Human RGS6 siRNA - orb266910 from Biorbyt
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RGS6 shRNA Plasmid (Human) - CHH6408 from Cohesion Biosciences
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