Gene Symbol | CAMK2A |
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Entrez Gene | 815 |
Alt Symbol | CAMKA |
Species | Human |
Gene Type | protein-coding |
Description | calcium/calmodulin-dependent protein kinase II alpha |
Other Description | CaM kinase II alpha subunit|CaM-kinase II alpha chain|CaMK-II alpha subunit|CaMKIINalpha|caM kinase II subunit alpha|caMK-II subunit alpha|calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha|calcium/calmodulin-dependent protein kinase II alpha-B subunit|calcium/calmodulin-dependent protein kinase type II alpha chain|calcium/calmodulin-dependent protein kinase type II subunit alpha |
Swissprots | Q9Y352 Q9UQM7 Q9Y2H4 Q9UL21 |
Accessions | ABD59008 EAW61741 EAW61742 Q9UQM7 AB023185 BAA76812 AF091486 AAD55815 AF145710 AAD30558 AF145711 AAD30559 AK289776 BAF82465 AK308853 AY429524 BC040457 AAH40457 BF951952 EU832105 ACE87455 EU832199 ACE86769 NM_015981 NP_057065 NM_171825 NP_741960 |
Function | CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). {ECO:0000250}. |
Subcellular Location | Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic lipid rafts. {ECO:0000250}. |
Top Pathways | Wnt signaling pathway, Glucagon signaling pathway, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels |
CaMKIIα CRISPR/Cas9 KO Plasmid (h) - sc-400228 from Santa Cruz Biotechnology
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CaMKIIα HDR Plasmid (h) - sc-400228-HDR from Santa Cruz Biotechnology
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CaMKIIα Double Nickase Plasmid (h) - sc-400228-NIC from Santa Cruz Biotechnology
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CaMKIIα Double Nickase Plasmid (h2) - sc-400228-NIC-2 from Santa Cruz Biotechnology
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CaMKIIα CRISPR Activation Plasmid (h) - sc-400228-ACT from Santa Cruz Biotechnology
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CaMKIIα CRISPR Activation Plasmid (h2) - sc-400228-ACT-2 from Santa Cruz Biotechnology
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CaMKIIα Lentiviral Activation Particles (h) - sc-400228-LAC from Santa Cruz Biotechnology
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CaMKIIα Lentiviral Activation Particles (h2) - sc-400228-LAC-2 from Santa Cruz Biotechnology
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CaMKIIα siRNA (h) - sc-29900 from Santa Cruz Biotechnology
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CaMKIIα shRNA Plasmid (h) - sc-29900-SH from Santa Cruz Biotechnology
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CaMKIIα shRNA (h) Lentiviral Particles - sc-29900-V from Santa Cruz Biotechnology
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CaM Kinase II alpha RNAi - H00000815-R04 from Novus Biologicals
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MISSION® esiRNA - EHU068101 from Sigma-Aldrich
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MISSION® siRNA - SIHK0245 from Sigma-Aldrich
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MISSION® siRNA - SIHK0244 from Sigma-Aldrich
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MISSION® siRNA - SIHK0243 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1528 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1529 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1528 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1529 from Sigma-Aldrich
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CAMK2A siRNA (Human) - CRH0569 from Cohesion Biosciences
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CaM Kinase II alpha RNAi - H00000815-R03 from Novus Biologicals
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CAMK2A - MBS8240417 from MyBioSource
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shRNA set against Human CAMK2A (NM_015981.3) - SHH253985 from Creative biogene
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Human CAMK2A siRNA - orb261071 from Biorbyt
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