| Gene Symbol |
PLCE1
|
| Entrez Gene |
51196
|
| Alt Symbol |
NPHS3, PLCE, PPLC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, epsilon 1
|
| Other Description |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1|PLC-epsilon-1|pancreas-enriched phospholipase C|phosphoinositide phospholipase C-epsilon-1|phosphoinositide-specific phospholipase C epsilon-1
|
| Swissprots |
Q9UHV3 A7MBN7 A6NLA1 A8K1D7 Q1X6H8 Q5VWL5 Q5VWL4 Q9H9X8 B9EIJ6 Q9HC53 Q9P212 Q9HBX6 A6NGW0
|
| Accessions |
CCQ43538 EAW50042 EAW50043 Q9P212 AB040949 BAA96040 AF117948 AAF22005 AF170071 AAG28341 AF190642 AAG17145 AK022543 BAB14090 AK074239 AK289852 BAF82541 AK297779 BAG60124 AL050031 AY995135 AAY45890 BC140705 AAI40706 BC144286 AAI44287 BC151854 AAI51855 BX491865 XM_006717885 XP_006717948 XM_006717886 XP_006717949 XM_006717888 XP_006717951 XM_006717889 XP_006717952 XM_006717890 XP_006717953 XM_011539849 XP_011538151 XM_011539850 XP_011538152 XM_011539851 XP_011538153 XM_011539852 XP_011538154 NM_001165979 NP_001159451 NM_001288989 NP_001275918 NM_016341 NP_057425
|
| Function |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182}.
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.
|
| Tissue Specificity |
Widely expressed. Isoform 1 is broadly expressed and only absent in peripheral blood leukocytes. Isoform 2 is specifically expressed in placenta, lung and spleen. {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11022048, ECO:0000269|PubMed:15558028}.
|
| Top Pathways |
Calcium signaling pathway, cAMP signaling pathway, Rap1 signaling pathway, Proteoglycans in cancer, Inositol phosphate metabolism
|