Gene Symbol | AGFG1 |
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Entrez Gene | 3267 |
Alt Symbol | HRB, RAB, RIP |
Species | Human |
Gene Type | protein-coding |
Description | ArfGAP with FG repeats 1 |
Other Description | HIV-1 Rev binding protein|HIV-1 Rev-binding protein|Rab, Rev/Rex activation domain-binding protein|arf-GAP domain and FG repeat-containing protein 1|arf-GAP domain and FG repeats-containing protein 1|hRIP, Rev interacting protein|nucleoporin-like protein RIP|rev-interacting protein|rev/Rex activation domain-binding protein |
Swissprots | E9PHX7 Q4VAS1 Q15277 Q4VAS0 Q53QT8 P52594 Q4VAS3 B3KUL1 Q53R11 |
Accessions | AAC37580 AAX93270 AAY24254 EAW70871 EAW70872 P52594 AA676544 AI742626 AI955214 AK097451 BAG53473 AK295030 BAG58086 BC030592 AAH30592 BC039332 BC045581 BC096272 AAH96272 BC096273 AAH96273 BC096274 AAH96274 BC096275 AAH96275 BE843894 BM474292 BQ016135 BX648387 CB990608 DB456989 X89478 CAA61667 XM_005246516 XP_005246573 XM_006712478 XP_006712541 XM_006712479 XP_006712542 XM_006712480 XP_006712543 XM_006712481 XP_006712544 XM_011511071 XP_011509373 XM_011511072 XP_011509374 NM_001135187 NP_001128659 NM_001135188 NP_001128660 NM_001135189 NP_001128661 NM_004504 NP_004495 |
Function | Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}. |
Subcellular Location | Nucleus. Cytoplasmic vesicle. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:7634337}. |
Top Pathways | Influenza A |
RIP/Rab CRISPR/Cas9 KO Plasmid (h) - sc-405836 from Santa Cruz Biotechnology
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RIP/Rab HDR Plasmid (h) - sc-405836-HDR from Santa Cruz Biotechnology
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RIP/Rab Double Nickase Plasmid (h) - sc-405836-NIC from Santa Cruz Biotechnology
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RIP/Rab Double Nickase Plasmid (h2) - sc-405836-NIC-2 from Santa Cruz Biotechnology
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RIP/Rab CRISPR Activation Plasmid (h) - sc-405836-ACT from Santa Cruz Biotechnology
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RIP/Rab CRISPR Activation Plasmid (h2) - sc-405836-ACT-2 from Santa Cruz Biotechnology
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RIP/Rab Lentiviral Activation Particles (h) - sc-405836-LAC from Santa Cruz Biotechnology
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RIP/Rab Lentiviral Activation Particles (h2) - sc-405836-LAC-2 from Santa Cruz Biotechnology
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RIP/Rab siRNA (h) - sc-40913 from Santa Cruz Biotechnology
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RIP/Rab shRNA Plasmid (h) - sc-40913-SH from Santa Cruz Biotechnology
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RIP/Rab shRNA (h) Lentiviral Particles - sc-40913-V from Santa Cruz Biotechnology
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HIV-1 Rev binding protein (HRB) RNAi - H00003267-R01 from Novus Biologicals
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MISSION® esiRNA - EHU010981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2942 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2942 from Sigma-Aldrich
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AGFG1 siRNA (Human) - CRH2235 from Cohesion Biosciences
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AGFG1 - MBS8202755 from MyBioSource
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RIP/Rab CRISPR/Cas9 KO Plasmid (h2) - sc-405836-KO-2 from Santa Cruz Biotechnology
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RIP/Rab HDR Plasmid (h2) - sc-405836-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human AGFG1 (NM_004504.4) - SHH233242 from Creative biogene
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Human AGFG1 siRNA - orb262737 from Biorbyt
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AGFG1 shRNA Plasmid (Human) - CHH2235 from Cohesion Biosciences
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AGFG1 miRNA 3'UTR clone - MiUTR4H-TG00209 from Creative biogene
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