| Gene Symbol |
ODF2
|
| Entrez Gene |
4957
|
| Alt Symbol |
CT134, ODF2/1, ODF2/2, ODF84
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
outer dense fiber of sperm tails 2
|
| Other Description |
cancer/testis antigen 134|cenexin 1|outer dense fiber of sperm tails, 84-kD|outer dense fiber protein 2|sperm tail structural protein
|
| Swissprots |
O14721 O60631 B4DZ02 Q5BJF6 E7EWL2 B4DRK4 B4DX73 Q1W2J6 Q96FN2 B1AND3 Q7Z5I6 Q6UN26 F5H6J4
|
| Accessions |
AAD22544 EAW87791 EAW87792 EAW87793 EAW87794 EAW87795 EAW87796 EAW87797 EAW87798 EAW87799 EAW87800 EAW87801 Q5BJF6 AF012549 AAB66337 AF053970 AAC08409 AK093367 BAG52697 AK126816 AK295662 BAG58524 AK299303 BAG61316 AK300793 BAG62452 AK301754 BAG63215 AK301842 BAG63285 AK301855 BAG63297 AK302684 BAG63914 AK308278 AK309917 AY319414 AAP83847 AY366499 AAQ73195 BC010629 AAH10629 BC012785 AAH12785 BC091500 AAH91500 BI825445 BI831601 BM563800 BM928430 DB044506 DB051583 DB094573 DB511337 DC397869 DC398295 DQ444713 ABE01856 DQ444714 ABE01857 EU832104 ACE87454 EU832188 ACE86758 EU832198 ACE86768 XM_005252010 XP_005252067 XM_005252011 XP_005252068 XM_005252012 XP_005252069 XM_005252013 XP_005252070 XM_005252014 XP_005252071 XM_005252016 XP_005252073 XM_005252017 XP_005252074 XM_005252018 XP_005252075 XM_005252019 XP_005252076 XM_005252020 XP_005252077 XM_005252022 XP_005252079 XM_005252023 XP_005252080 XM_005252024 XP_005252081 XM_005252025 XP_005252082 XM_005252026 XP_005252083 XM_005252027 XP_005252084 XM_005252028 XP_005252085 XM_005252029 XP_005252086 XM_006717126 XP_006717189 XM_011518722 XP_011517024 XM_011518723 XP_011517025 XM_011518724 XP_011517026 XM_011518725 XP_011517027 XM_011518726 XP_011517028 XM_011518727 XP_011517029 XM_011518728 XP_011517030 XM_011518729 XP_011517031 XM_011518730 XP_011517032 XM_011518731 XP_011517033 XM_011518732 XP_011517034 XM_011518733 XP_011517035 XM_011518734 XP_011517036 XM_011518735 XP_011517037 XM_011518736 XP_011517038 XM_011518737 XP_011517039 XM_011518738 XP_011517040 XM_011518739 XP_011517041 XM_011518740 XP_011517042 XM_011518741 XP_011517043 XM_011518742 XP_011517044 XM_011518743 XP_011517045 XM_011518744 XP_011517046 NM_001242352 NP_001229281 NM_001242353 NP_001229282 NM_001242354 NP_001229283 NM_002540 NP_002531 NM_153432 NP_702910 NM_153433 NP_702911 NM_153435 NP_702913 NM_153436 NP_702914 NM_153437 NP_702915 NM_153439 NP_702917 NM_153440 NP_702918
|
| Function |
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.
|
| Tissue Specificity |
Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails. {ECO:0000269|PubMed:10381817}.
|