| Gene Symbol |
piwi
|
| Entrez Gene |
34521
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| Alt Symbol |
CG6122, Dmel\CG6122, PIWI, Piwi
|
| Species |
Drosophila
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| Gene Type |
protein-coding
|
| Description |
CG6122 gene product from transcript CG6122-RA
|
| Other Description |
CG6122-PA|CG6122-PB|P-element induced wimpy testis|piwi-PA|piwi-PB
|
| Swissprots |
K7XHZ2 K7WS94 K7WQ39 L0CRU0 Q9VKM1 L0CRI5 L0CRH9 K7WKT2 O96674 L0CPS4 O96675 Q6NNZ4 C0PTU6 L0CPR8 L0CR36 Q6NP34 K7WKS7 L0CQ04
|
| Accessions |
AAF53043 AGL81526 AGL81531 AHN54339 Q9VKM1 NM_001298896 NP_001285825 NM_057527 NP_476875
|
| Function |
Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael- dependent manner. In germ cells, mediates silencing at both transcriptional and post-transcriptional levels and is involved in the maintenance of populations of primary and secondary piRNAs. Piwi-mediated transcriptional silencing is accompanied by the formation of His3 'Lys-9' trimethylated (H3K9me3) euchromatin and heterochromatin. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. Associat
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleoplasm. Note=Component of polar granules. Present in the cytoplasm of the developing oocyte. At the mitotic cycle 11 translocates to the nucleus where it remains localized throughout germ-cell development and gonadogenesis. Localizes at genomic sites enriched for methylated H3K9.
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| Tissue Specificity |
Expressed somatically in ovariole terminal filament cells, epithelial sheath cells, cap cells and follicle cells (at protein level). Expressed in nurse cells and oocytes in developing egg chambers (at protein level). In embryos, accumulates in pole cells (at protein level). In larval and adult testis, expressed in a germinal proliferative center at the apical tip containing somatic hub cells and mitotically dividing germ stem cells (at protein level). {ECO:0000269|PubMed:10631171, ECO:0000269|PubMed:15817569, ECO:0000269|PubMed:16882972, ECO:0000269|PubMed:16949822, ECO:0000269|PubMed:17346786, ECO:0000269|PubMed:17875665, ECO:0000269|PubMed:19377467, ECO:0000269|PubMed:23297219, ECO:0000269|PubMed:9199372, ECO:0000269|PubMed:9851978}.
|
| Top Pathways |
Dorso-ventral axis formation
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