TRIM5

Gene Symbol	TRIM5
Entrez Gene	85363
Alt Symbol	RNF88, TRIM5alpha
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 5
Other Description	ring finger protein 88|tripartite motif containing 5 transcript variant iota|tripartite motif containing 5 transcript variant kappa|tripartite motif protein TRIM5|tripartite motif-containing protein 5
Swissprots	Q8WU46 Q2MLV8 Q2MLX5 Q9C032 Q2MLY4 Q2MLW6 D3DQS9 Q2MLX2 Q9C033 Q2V6Q6 G3GJY1 Q2MLV4 Q9C035 Q2MLW1 Q96SR5 Q2MLW3 Q2MLX1 Q2MLV9 A8WFA8 A6NGQ1 Q2MLY3 D3DQS8 Q6GX26 Q2MLW7 Q9C034 Q2MLX3 Q9C031 Q2MLW4
Accessions	ABC00997 ABC00998 ABC00999 ABC01000 ABC01001 ABC01002 ABC01003 ABC01004 ABC01005 ABC01006 ABC01007 ABC01008 ABC01009 ABC01010 ABC01011 ABC01012 ABC01013 ABC01014 ABC01015 ABC01016 ABC01017 ABC01018 ABC01019 ABC01020 ABC01021 ABC01022 ABC01023 ABC01024 ABC01025 ABC01026 ABC01027 ABC01028 ABC01029 ABC01030 ABC01031 ABC01032 ABC01033 ABW96352 ACY29365 ACY29366 ACY29367 ACY29368 ACY29369 ACY29370 ACY29371 ACY29372 ACY29373 ACY29374 EAW68771 EAW68772 EAW68773 EAW68774 EAW68775 EAW68776 EAW68777 Q9C035 AB362928 BAG16811 AF220025 AAG53479 AF220026 AAG53480 AF220027 AAG53481 AF220028 AAG53482 AF220029 AAG53483 AK027593 BAB55218 AK074363 AY625000 AAT48101 BC020770 AAH20770 BC021258 AAH21258 BX647152 CN334837 DA475412 DQ288685 ABB90543 HG503469 HQ447250 ADQ31737 JF928461 AEN14475 JF928462 AEN14476 XM_005253183 XP_005253240 XM_005253184 XP_005253241 XM_006718358 XP_006718421 XM_011520424 XP_011518726 XM_011520425 XP_011518727 XM_011520426 XP_011518728 XM_011520427 XP_011518729 XR_930919 XR_930920 XR_930921 NM_033034 NP_149023 NM_033092 NP_149083 NM_033093 NP_149084
Function	Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF- kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropi
Subcellular Location	Cytoplasm, P-body {ECO:0000269|PubMed:12878161, ECO:0000269|PubMed:20357094}. Note=Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TRIM5 gamma peptide - ab41839 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human TRIM5 alpha peptide - ab39887 from Abcam Category Peptide Species Human

Human TRIM5 alpha protein fragment - ab164745 from Abcam Category Protein Source Wheat germ Species Human

Human TRIM5 delta full length protein - ab132291 from Abcam Category Protein Source Wheat germ Species Human

Human TRIM5 delta peptide - ab41855 from Abcam Category Peptide Species Human

Human TRIM5 delta protein fragment - ab196078 from Abcam Category Protein Source HEK 293 cells Species Human

TRIM5 Antibody Blocking Peptide - LS-E1190 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM5 Antibody Blocking Peptide - LS-E25535 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM5 Antibody Blocking Peptide - LS-E14413 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM5 Antibody Blocking Peptide - LS-E26024 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM5 Antibody Blocking Peptide - LS-E30050 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRIM5 Antibody Blocking Peptide - LS-E30052 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRIM5 Antibody Blocking Peptide - LS-E30051 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRIM5 Antibody Blocking Peptide - LS-E30049 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRIM5 Antibody Blocking Peptide - LS-E30053 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TRIM5 Protein - H00085363-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRIM5 Recombinant Protein - H00085363-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRIM5 alpha Blocking Peptide - NBP1-76600PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg

TRIM5-Antibody-C-term-Blocking-peptide - BP11747b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIM5 (alpha isoform) blocking peptide - GTX89426-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TRIM5 blocking peptide - GTX47603-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TRIM5 Immunizing peptide - orb17094 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TRIM5 Blocking Peptide - 33R-1776 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRIM5 Peptide - AC21-0364-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRIM5 Peptide - AC21-0852-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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