| Gene Symbol |
ARID1A
|
| Entrez Gene |
8289
|
| Alt Symbol |
B120, BAF250, BAF250a, BM029, C1orf4, ELD, MRD14, OSA1, P270, SMARCF1, hELD, hOSA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
AT rich interactive domain 1A (SWI-like)
|
| Other Description |
ARID domain-containing protein 1A|AT-rich interactive domain-containing protein 1A|BRG1-associated factor 250a|OSA1 nuclear protein|SWI-like protein|SWI/SNF complex protein p270|SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1|brain protein 120|chromatin remodeling factor p250|osa homolog 1
|
| Swissprots |
Q53FK9 Q5T0W2 Q5T0W3 Q9UPZ1 Q9BY33 D3DPL1 O14497 Q96T89 Q9HBJ5 Q5T0W1 Q8NFD6
|
| Accessions |
BAA83073 EAX07793 EAX07794 EAX07795 EAX07796 EAX07797 O14497 AB001895 BAA23269 AB210022 BAE06104 AF217506 AAF67617 AF219114 AAG17549 AF231056 AAG33967 AF265208 AAF75765 AF268913 AAK54505 AF521670 AAN03446 AK027442 BAB55114 AK027467 BAB55132 AK027655 BAB55270 AK074940 BAC11306 AK223275 BAD96995 AK308363 BC112895 AAI12896 NM_006015 NP_006006 NM_139135 NP_624361 NM_018450
|
| Function |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capa
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000269|PubMed:11318604}.
|
| Tissue Specificity |
Highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and PBL, and at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. {ECO:0000269|PubMed:11073988, ECO:0000269|PubMed:11318604, ECO:0000269|PubMed:12200431}.
|